Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 7/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1936426 | 0.94 | HTR4 (0.39) | HTR4CCR5PGRACHEUTS2R | |
| SCHEMBL2541058 | 0.93 | CCR5 (0.41) | HTR4CCR5PGRACHECHRM3 | |
| SCHEMBL3364749 | 0.91 | ACHE (0.43) | HTR4CCR5PGRACHEUTS2R | |
| SCHEMBL1937163 | 0.90 | HTR4 (0.41) | HTR4PGRACHEOPRM1 | |
| SCHEMBL2395603 | 0.88 | CCR5 (0.41) | CCR5PGRUTS2ROPRK1CHRM3 | |
| Fumaric Acid SCHEMBL2548804 | 0.88 | CCR5 (0.38) | HTR4CCR5PGRACHESLC6A2 | |
| Hydrochloric Acid SCHEMBL2396854 | 0.87 | OPRM1 (0.41) | CCR5PGRUTS2ROPRK1CHRM3 | |
| SCHEMBL1936605 | 0.86 | HTR4 (0.44) | HTR4UTS2ROPRK1CHRM3SLC6A2 | |
| Fumaric Acid SCHEMBL1936521 | 0.85 | ACHE (0.41) | HTR4CCR5PGRACHEUTS2R | |
| SCHEMBL1937662 | 0.85 | SLC6A4 (0.46) | HTR4ACHEOPRK1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218217-A1 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | NEUROSEARCH A/S (DK) | 2011-09-08 | — | — | US | claimed |
| EP-2331504-A2 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | NeuroSearch A/S (DK) | 2011-06-15 | — | — | EP | claimed |
| WO-2010023196-A2 | NOVEL PIPERIDINE-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2010-03-04 | — | — | WO | claimed |
| US-20110218217-A1 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | NEUROSEARCH A/S (DK) | 2011-09-08 | — | — | US | disclosed |
| EP-2331504-A2 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | NeuroSearch A/S (DK) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010023196-A2 | NOVEL PIPERIDINE-PROPIONAMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218217-A1 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER | SLC18A2, SLC1A2, PNMT | HTR4 16/4885CCR5 881/4885PGR 2100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.