Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.43 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 14/20 | 0.41 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19375493 | 0.79 | ALDH1A1 (0.38) | TRPC4TRPC5KCNH2P2RX3ALDH1A1 | |
| SCHEMBL19375187 | 0.79 | TRPC4 (0.44) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19375563 | 0.78 | PDE5A (0.39) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19375219 | 0.77 | TRPC4 (0.46) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19375544 | 0.77 | ADORA3 (0.35) | ALDH1A1ADORA3PDE5A | |
| SCHEMBL18833767 | 0.76 | TRPC5 (0.51) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL20432532 | 0.76 | PDE5A (0.33) | ADORA3PDE5A | |
| SCHEMBL19505572 | 0.76 | TRPC4 (0.47) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19375680 | 0.75 | TRPC4 (0.46) | TRPC4TRPC5KCNH2P2RX3TRPC1 | |
| SCHEMBL19375602 | 0.75 | ADORA3 (0.43) | TRPC4TRPC5KCNH2TRPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |