Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.39 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834945 | 0.81 | TRPC4 (0.39) | PDE5ATRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL19375494 | 0.78 | TRPC4 (0.43) | PDE5ATRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL19375124 | 0.78 | TRPC4 (0.37) | PDE5ATRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL19375187 | 0.77 | TRPC4 (0.44) | PDE5ATRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL19375611 | 0.74 | TRPC4 (0.41) | PDE5ATRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL19375436 | 0.74 | P2RX7 (0.35) | PDE5ATRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL16028200 | 0.73 | TRPC5 (0.60) | TRPC4TRPC5KCNH2TRPC1P2RX3 | |
| SCHEMBL16028737 | 0.72 | TRPC5 (0.71) | TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL19375040 | 0.72 | RAB9A (0.36) | P2RX3 | |
| SCHEMBL18834254 | 0.72 | TRPC4 (0.40) | PDE5ATRPC4TRPC5KCNH2TRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |