Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MDM4 | O15151 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19420605 | 0.87 | TRPA1 (0.42) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL19420603 | 0.66 | CYP3A4 (0.41) | TRPA1PTGS1ALDH1A1HTTALOX12 | |
| SCHEMBL19420597 | 0.66 | GABRA1 (0.41) | TRPA1PTGS1ALDH1A1HTTALOX12 | |
| SCHEMBL19420602 | 0.66 | UGT2B7 (0.35) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL11651790 | 0.65 | TRPA1 (0.64) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| Hydrogen Peroxide SCHEMBL9840257 | 0.65 | UGT2B7 (0.60) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| Hydrogen Peroxide SCHEMBL9172508 | 0.65 | UGT2B7 (0.60) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL17707911 | 0.65 | TRPA1 (0.47) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL8897330 | 0.65 | TRPA1 (0.47) | TRPA1PTGS1CACNA1CALDH1A1HTT | |
| SCHEMBL4832080 | 0.64 | UGT2B7 (0.52) | TRPA1PTGS1CACNA1CALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170281532-A1 | 2 SUBSTITUTED CEPHEM COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281532-A1 | 2 SUBSTITUTED CEPHEM COMPOUNDS | CEP170, CES2, CMBL | TRPA1 3612/4885PTGS1 2702/4885CACNA1C 3434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.