Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KCNJ6 | P48051 | 13/20 | 0.44 |
| ▸ | KCNJ3 | P48549 | 13/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 8/20 | 0.42 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377699 | 0.85 | KEAP1 (0.52) | NPC1LMNATP53PKMRAB9A | |
| SCHEMBL30672491 | 0.83 | NPC1 (0.51) | NPC1LMNATP53PKMRAB9A | |
| SCHEMBL21777246 | 0.74 | KCNJ6 (0.45) | SMN1; SMN2KCNJ6KCNJ3KCNJ5CRACR2A | |
| SCHEMBL29052238 | 0.74 | PPARA (0.53) | SMN1; SMN2KCNJ6KCNJ3KCNJ5CRACR2A | |
| SCHEMBL31522194 | 0.74 | NPC1 (0.59) | NPC1LMNATP53PKMRAB9A | |
| SCHEMBL22896928 | 0.72 | ALDH1A1 (0.55) | NPC1LMNATP53PKMRAB9A | |
| SCHEMBL1011586 | 0.69 | RAB9A (0.88) | NPC1LMNATP53PKMRAB9A | |
| SCHEMBL4513114 | 0.69 | KCNJ6 (0.72) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL28330785 | 0.68 | NPC1 (0.56) | NPC1LMNATP53PKMRAB9A | |
| SCHEMBL29052610 | 0.68 | PPARA (0.45) | SMN1; SMN2KCNJ6KCNJ3KCNJ5CRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017172596-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION (US) | 2017-10-05 | — | — | WO | disclosed |