Sugi Predict

Sugi Predict / Compounds / SCHEMBL1944076

SCHEMBL1944076

SCHEMBL1944076

O=C(O)c1cccn(C(F)F)c1=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 11/20 0.58
▸ ALDH1A1 P00352 4/20 0.41
▸ ALOX15 P16050 1/20 0.41
▸ KDM4E B2RXH2 2/20 0.40
▸ CASP1 P29466 1/20 0.40
▸ CASP7 P55210 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ MAPT P10636 2/20 0.39
▸ HDAC8 Q9BY41 1/20 0.39
▸ L3MBTL1 Q9Y468 2/20 0.39
▸ POLB P06746 1/20 0.39
▸ APEX1 P27695 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39
▸ LMNA P02545 1/20 0.37
▸ NAPRT Q6XQN6 2/20 0.36
▸ CA12 O43570 1/20 0.36
▸ CA1 P00915 1/20 0.36
▸ CA2 P00918 1/20 0.36
▸ HMGB1 P09429 1/20 0.36
▸ HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22234491 0.84 PTGS2 (0.53) PTGS2ALDH1A1KDM4EHSD17B10MAPT
SCHEMBL27189188 0.84 PTGS2 (0.53) PTGS2ALDH1A1ALOX15KDM4EMAPT
SCHEMBL11634695 0.81 PTGS2 (0.45) PTGS2ALDH1A1ALOX15KDM4ECASP1
SCHEMBL20524639 0.80 PTGS2 (0.51) PTGS2ALDH1A1ALOX15KDM4EHSD17B10
SCHEMBL4427312 0.79 ALDH1A1 (0.43) PTGS2ALDH1A1ALOX15KDM4ECASP1
SCHEMBL4430871 0.77 KDM4E (0.40) PTGS2ALDH1A1KDM4ECASP1CASP7
SCHEMBL1137260 0.76 ALDH1A1 (0.48) PTGS2ALDH1A1ALOX15KDM4ECASP1
SCHEMBL19377768 0.76 PTGS2 (0.41) PTGS2ALDH1A1ALOX15KDM4ECASP1
SCHEMBL2621624 0.76 ALDH1A1 (0.48) PTGS2ALDH1A1ALOX15KDM4ECASP1
SCHEMBL26613626 0.76 PTGS2 (0.41) PTGS2ALDH1A1ALOX15KDM4ECASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4698517-A1 <SUP2/>? <SUB2/>?4?NOVEL COMPOUNDS AS ?? <NS1:SUB>7</NS1:SUB>?INHIBITORS Evotec International GmbH (DE) 2026-02-25 — — EP disclosed
US-20250361223-A1 AMIDE COMPOUNDS AND USES THEREOF HUTCHISON MEDIPHARMA LTD (CN) 2025-11-27 — — US disclosed
US-12435062-B2 Amide compounds and uses thereof HUTCHISON MEDIPHARMA LIMITED (CN) 2025-10-07 — — US disclosed
WO-2024218058-A1 NOVEL COMPOUNDS AS α4β7 INHIBITORS EVOTEC INTERNATIONAL GMBH (DE) 2024-10-24 — — WO disclosed
CN-117777103-A Amide compound and application thereof 和记黄埔医药（上海）有限公司 2024-03-29 — — CN disclosed
CN-117720519-A Amide compound and application thereof 和记黄埔医药（上海）有限公司 2024-03-19 — — CN disclosed
CN-117720520-A Amide compound and application thereof 和记黄埔医药（上海）有限公司 2024-03-19 — — CN disclosed
CN-115315422-B Amide compound and application thereof 和记黄埔医药（上海）有限公司 2023-11-07 — — CN disclosed
US-20230174513-A1 AMIDE COMPOUNDS AND USES THEREOF HUTCHISON MEDIPHARMA LIMITED (CN) 2023-06-08 — — US disclosed
US-20230174513-A1 AMIDE COMPOUNDS AND USES THEREOF HUTCHISON MEDIPHARMA LIMITED (CN) 2023-06-08 — — US disclosed
US-20220089592-A1 IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AS IRAK4 INHIBITORS BIOGEN MA INC. 2022-03-24 — — US disclosed
EP-3911652-A1 IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AS IRAK4 INHIBITORS Biogen MA Inc. (US) 2021-11-24 — — EP disclosed
WO-2021197276-A1 Amide compounds and uses thereof HUTCHISON MEDIPHARMA LIMITED (CN) 2021-10-07 — — WO disclosed
US-20200375969-A1 PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 TAKEDA CALIFORNIA, INC. 2020-12-03 — — US disclosed
US-20200375969-A1 PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 TAKEDA CALIFORNIA, INC. 2020-12-03 — — US disclosed
WO-2020200899-A1 NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS GALAPAGOS NV (BE) 2020-10-08 — — WO disclosed
WO-2020150626-A1 IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AS IRAK4 INHIBITORS BIOGEN MA INC. (US) 2020-07-23 — — WO disclosed
WO-2020150626-A1 IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AS IRAK4 INHIBITORS BIOGEN MA INC. (US) 2020-07-23 — — WO disclosed
US-20110130406-A1 PYRAZOLO-PYRIDINES AS TYROSINE KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2011-06-02 — — US disclosed
CN-101918403-A Pyrazolo-pyridines as tyrosine kinase inhibitor ARRAY BIOPHARMA INC 2010-12-15 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200375969-A1 PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6 GPR6, GPR3, GPR68 PTGS2 1542/4885ALDH1A1 2339/4885ALOX15 2825/4885
US-20230174513-A1 AMIDE COMPOUNDS AND USES THEREOF ASNS, ASS1, NAT1 PTGS2 1586/4885ALDH1A1 610/4885ALOX15 1673/4885
US-20110130406-A1 PYRAZOLO-PYRIDINES AS TYROSINE KINASE INHIBITORS TYRO3, LCK, LTK PTGS2 1964/4885ALDH1A1 1744/4885ALOX15 3124/4885
US-12435062-B2 Amide compounds and uses thereof ASNS, ASS1, NAT1 PTGS2 1586/4885ALDH1A1 610/4885ALOX15 1673/4885
US-20250361223-A1 AMIDE COMPOUNDS AND USES THEREOF ASNS, NAT1, AADAC PTGS2 1918/4885ALDH1A1 585/4885ALOX15 2280/4885
US-20220089592-A1 IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AS IRAK4 INHIBITORS IRAK4, IRAK2, IRAK1 PTGS2 2609/4885ALDH1A1 1657/4885ALOX15 4320/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.