Sugi Predict

Sugi Predict / Compounds / SCHEMBL194573

SCHEMBL194573

SCHEMBL194573

CSc1[nH]c(-c2ccc3ccccc3c2)cc1C#N

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B10 Q99714 2/20 0.45
▸ ALDH1A1 P00352 2/20 0.45
▸ CYP1A2 P05177 1/20 0.45
▸ HPGD P15428 1/20 0.45
▸ PIM1 P11309 1/20 0.44
▸ MAP2K2 P36507 2/20 0.43
▸ MAP2K1 Q02750 2/20 0.43
▸ CA1 P00915 1/20 0.41
▸ CA2 P00918 1/20 0.41
▸ KDM4E B2RXH2 3/20 0.40
▸ PDE9A O76083 1/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ RXFP1 Q9HBX9 1/20 0.39
▸ TRPA1 O75762 1/20 0.39
▸ CYP11B1 P15538 1/20 0.39
▸ CYP11B2 P19099 1/20 0.39
▸ MAPT P10636 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ MET P08581 1/20 0.37
▸ KDR P35968 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29816254 1.00 HSD17B10 (0.45) HSD17B10ALDH1A1CYP1A2HPGDPIM1
SCHEMBL194725 0.83 ALDH1A1 (0.54) HSD17B10ALDH1A1HPGDKDM4EKMT2A
SCHEMBL15996314 0.78 AR (0.48) HSD17B10ALDH1A1HPGDKDM4EKMT2A
SCHEMBL29816169 0.77 GAA (0.60) ALDH1A1HPGDKDM4ERXFP1MAPT
SCHEMBL10278151 0.77 GAA (0.60) ALDH1A1HPGDKDM4ERXFP1MAPT
SCHEMBL13182042 0.77 PTGES (0.43) HSD17B10ALDH1A1KDM4EKMT2ARXFP1
SCHEMBL194128 0.77 AXL (0.45) HSD17B10ALDH1A1CYP1A2KDM4EKMT2A
SCHEMBL194257 0.75 MAP2K2 (0.60) ALDH1A1CYP1A2MAP2K2MAP2K1CA1
SCHEMBL29816227 0.75 MAP2K2 (0.60) ALDH1A1CYP1A2MAP2K2MAP2K1CA1
SCHEMBL10278516 0.75 AR (0.43) HSD17B10ALDH1A1HPGDKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12351553-B2 Process for producing 5-aryl-1H-pyrolle-3-carbonitrile compounds by dehalogenation TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2025-07-08 — — US disclosed
US-20230088365-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-03-23 — — US disclosed
US-11498898-B2 Process for producing pyrrole compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2022-11-15 — — US disclosed
CN-114835619-A Process for preparing azole compounds 武田药品工业株式会社 2022-08-02 — — CN disclosed
EP-3929187-A2 PROCESS FOR PRODUCING PYRROLE COMPOUND Takeda Pharmaceutical Company Limited (JP) 2021-12-29 — — EP disclosed
EP-3929187-A2 PROCESS FOR PRODUCING PYRROLE COMPOUND Takeda Pharmaceutical Company Limited (JP) 2021-12-29 — — EP disclosed
US-20210070705-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-03-11 — — US disclosed
US-20210070705-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-03-11 — — US disclosed
US-10844011-B2 Process for producing pyrrole compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-11-24 — — US disclosed
US-10844011-B2 Process for producing pyrrole compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-11-24 — — US disclosed
US-8822694-B2 Process for producing pyrrole compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-09-02 — — US disclosed
US-8822694-B2 Process for producing pyrrole compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-09-02 — — US disclosed
US-8822694-B2 Process for producing pyrrole compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-09-02 — — US disclosed
EP-2765130-A2 Process for producing pyrrole compound Takeda Pharmaceutical Company Limited (JP) 2014-08-13 — — EP disclosed
EP-2402313-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND Takeda Pharmaceutical Company Limited (JP) 2012-01-04 — — EP disclosed
EP-2402313-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND Takeda Pharmaceutical Company Limited (JP) 2012-01-04 — — EP disclosed
US-20110306769-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-12-15 — — US disclosed
US-20110306769-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-12-15 — — US disclosed
US-20110306769-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-12-15 — — US disclosed
WO-2010098351-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND 武田薬品工業株式会社 (JP) 2010-09-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210070705-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND DHPS, STS, HPD HSD17B10 1475/4885ALDH1A1 1184/4885CYP1A2 148/4885
US-12351553-B2 Process for producing 5-aryl-1H-pyrolle-3-carbonitrile compounds by dehalogenation CYP51A1, PAH, HPD HSD17B10 98/4885ALDH1A1 1045/4885CYP1A2 58/4885
US-20230088365-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND DHPS, STS, HPD HSD17B10 1475/4885ALDH1A1 1184/4885CYP1A2 148/4885
US-11498898-B2 Process for producing pyrrole compound DHPS, STS, HPD HSD17B10 1475/4885ALDH1A1 1184/4885CYP1A2 148/4885
US-10844011-B2 Process for producing pyrrole compound DHPS, STS, HPD HSD17B10 1475/4885ALDH1A1 1184/4885CYP1A2 148/4885
US-20110306769-A1 PROCESS FOR PRODUCING PYRROLE COMPOUND DHPS, STS, HPD HSD17B10 1475/4885ALDH1A1 1184/4885CYP1A2 148/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.