Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 7/20 | 0.50 |
| ▸ | CDK8 | P49336 | 7/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | RORB | Q92753 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19478319 | 0.84 | CCNC (0.39) | CCNCCDK8NUDT1SYKHASPIN | |
| SCHEMBL16571390 | 0.83 | CCNC (0.47) | CCNCCDK8NUDT1SYKPARP10 | |
| SCHEMBL16571150 | 0.80 | CCNC (0.45) | CCNCCDK8NUDT1SYKHASPIN | |
| SCHEMBL16571539 | 0.73 | CCNC (0.35) | CCNCCDK8NUDT1SYKJAK2 | |
| SCHEMBL16571148 | 0.72 | NUDT1 (0.43) | CCNCCDK8NUDT1SYKPARP10 | |
| SCHEMBL16570776 | 0.69 | XDH (0.36) | CCNCCDK8NUDT1SYKPARP10 | |
| SCHEMBL3709674 | 0.68 | XDH (0.68) | CCNCCDK8SYKJAK2HRH4 | |
| SCHEMBL17885922 | 0.68 | HRH4 (0.41) | CCNCCDK8NUDT1HRH4IDO1 | |
| SCHEMBL16580061 | 0.68 | PARP1 (0.39) | CCNCCDK8NUDT1HASPINJAK2 | |
| SCHEMBL16115998 | 0.67 | CCNC (1.00) | CCNCCDK8IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | claimed |