Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 15/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17592848 | 1.00 | HTR7 (1.00) | HTR7DRD2CARM1PRMT6SLC18A3 | |
| SCHEMBL17592912 | 1.00 | HTR7 (1.00) | HTR7DRD2CARM1PRMT6SLC18A3 | |
| Trifluoroacetic Acid SCHEMBL18227620 | 0.92 | HTR7 (0.84) | HTR7DRD2SLC18A3 | |
| SCHEMBL22219714 | 0.87 | HTR7 (0.76) | HTR7DRD2 | |
| SCHEMBL22219749 | 0.87 | HTR7 (0.76) | HTR7DRD2 | |
| SCHEMBL20465846 | 0.86 | HTR7 (0.76) | HTR7DRD2 | |
| SCHEMBL20465845 | 0.86 | HTR7 (0.76) | HTR7DRD2 | |
| SCHEMBL16150495 | 0.86 | HTR7 (0.75) | HTR7 | |
| SCHEMBL22219778 | 0.85 | HTR7 (0.73) | HTR7DRD2 | |
| SCHEMBL22219753 | 0.85 | HTR7 (0.73) | HTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180221365-A1 | NOVEL SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE | Temple University--of the Commonwealth System of Higher Education | 2018-08-09 | — | — | US | claimed |
| US-20170298037-A1 | Novel 5-Hydroxytryptamine Receptor 7 Activity Modulators and Their Method of Use | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-10-19 | — | — | US | claimed |
| EP-3200589-B1 | NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE | UNIV TEMPLE (US) | 2026-03-11 | — | — | EP | disclosed |
| US-12269809-B2 | 5-hydroxytryptamine receptor 7 activity modulators and their method of use | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2025-04-08 | — | — | US | disclosed |
| US-20220306596-A1 | NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE | Temple University--of the Commonwealth System of Higher Education | 2022-09-29 | — | — | US | disclosed |
| US-20220133713-A1 | SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE | Temple University--of the Commonwealth System of Higher Education | 2022-05-05 | — | — | US | disclosed |
| US-11192871-B2 | 5-hydroxytryptamine receptor 7 activity modulators and their method of use | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-12-07 | — | — | US | disclosed |
| US-20200223810-A1 | NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2020-07-16 | — | — | US | disclosed |
| US-10544117-B2 | 5-hydroxytryptamine receptor 7 activity modulators and their method of use | Temple University—Of the Commonwealth System of Higher Education (US) | 2020-01-28 | — | — | US | disclosed |
| US-20180221365-A1 | NOVEL SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE | Temple University--of the Commonwealth System of Higher Education | 2018-08-09 | — | — | US | disclosed |
| US-20170298037-A1 | Novel 5-Hydroxytryptamine Receptor 7 Activity Modulators and Their Method of Use | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11192871-B2 | 5-hydroxytryptamine receptor 7 activity modulators and their method of use | HTR7, HTR5A, HTR6 | HTR7 1/4885DRD2 261/4885CARM1 3438/4885 |
| US-20180221365-A1 | NOVEL SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE | SIGMAR1, TMEM97, OPRL1 | HTR7 83/4885DRD2 209/4885CARM1 4409/4885 |
| US-20220133713-A1 | SIGMA-2 RECEPTOR BINDERS AND THEIR METHOD OF USE | SIGMAR1, TMEM97, OPRL1 | HTR7 68/4885DRD2 273/4885CARM1 4016/4885 |
| US-20170298037-A1 | Novel 5-Hydroxytryptamine Receptor 7 Activity Modulators and Their Method of Use | HTR7, HTR6, HTR5A | HTR7 1/4885DRD2 328/4885CARM1 3996/4885 |
| US-20200223810-A1 | NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE | HTR7, HTR6, HTR5A | HTR7 1/4885DRD2 328/4885CARM1 3996/4885 |
| US-10544117-B2 | 5-hydroxytryptamine receptor 7 activity modulators and their method of use | HTR7, HTR5A, HTR6 | HTR7 1/4885DRD2 295/4885CARM1 3694/4885 |
| US-20220306596-A1 | NOVEL 5-HYDROXYTRYPTAMINE RECEPTOR 7 ACTIVITY MODULATORS AND THEIR METHOD OF USE | HTR7, HTR6, HTR5A | HTR7 1/4885DRD2 328/4885CARM1 3996/4885 |
| US-12269809-B2 | 5-hydroxytryptamine receptor 7 activity modulators and their method of use | HTR7, HTR5A, HTR6 | HTR7 1/4885DRD2 261/4885CARM1 3438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.