Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 3/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19459017 | 0.83 | KIT (0.39) | KITRET | |
| SCHEMBL19462890 | 0.77 | RET (0.45) | KITMAP4K4RET | |
| SCHEMBL21678301 | 0.76 | KIT (0.38) | KITRET | |
| SCHEMBL21679943 | 0.75 | KIT (0.40) | KITMAP4K4RET | |
| SCHEMBL19458940 | 0.74 | ALDH1A1 (0.44) | KITRET | |
| SCHEMBL19486444 | 0.73 | KIT (0.42) | KITMAP4K4RET | |
| SCHEMBL25767185 | 0.70 | CHRNA7 (0.36) | KITMAP4K4 | |
| SCHEMBL19491029 | 0.69 | KIT (0.33) | KITRET | |
| SCHEMBL19486329 | 0.69 | CHRNA7 (0.44) | KITMAP4K4 | |
| SCHEMBL19486469 | 0.68 | BMP4 (0.46) | KITMAP4K4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10233186-B2 | Inhibitors of activin receptor-like kinase | BLUEPRINT MEDICINES CORPORATION (US) | 2019-03-19 | — | — | US | disclosed |
| US-20170298069-A1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORPORATION | 2017-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10233186-B2 | Inhibitors of activin receptor-like kinase | ACVR1, ACVR2A, ACVRL1 | KIT 27/4885MAP4K4 439/4885RET 56/4885 |
| US-20170298069-A1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | ACVR1, ACVR2A, ACVRL1 | KIT 189/4885MAP4K4 312/4885RET 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.