Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (R)-3-Hydroxybutanoate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R)-3-Hydroxybutanoate SCHEMBL22321678 | 1.00 | CA2 (0.57) | CA2CA4SLC22A16CA1CTSL | |
| (R)-3-Hydroxybutanoate SCHEMBL7209004 | 1.00 | CA2 (0.57) | CA2CA4SLC22A16CA1CTSL | |
| (R)-3-Hydroxybutanoate SCHEMBL21225057 | 0.97 | CA2 (0.55) | CA2CA4SLC22A16CA1CTSL | |
| (R)-3-Hydroxybutanoate SCHEMBL30390135 | 0.97 | CA2 (0.55) | CA2CA4SLC22A16CA1CTSL | |
| (R)-3-Hydroxybutanoate SCHEMBL20518506 | 0.94 | CA2 (0.57) | CA2CA4SLC22A16CA1CTSL | |
| (R)-3-Hydroxybutanoate SCHEMBL22321684 | 0.94 | — | — | |
| (R)-3-Hydroxybutanoate SCHEMBL194589 | 0.94 | — | — | |
| (R)-3-Hydroxybutanoate SCHEMBL1330790 | 0.94 | — | — | |
| (R)-3-Hydroxybutanoate SCHEMBL21060562 | 0.94 | CA2 (0.57) | CA2CA4SLC22A16CA1CTSL | |
| (R)-3-Hydroxybutanoate SCHEMBL7765391 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12171735-B2 | Administration of butyrate, beta-hydroxybutyrate, cannabidiol, and related compounds in humans | AXCESS GLOBAL SCIENCES, LLC (US) | 2024-12-24 | — | — | US | claimed |
| US-12109182-B2 | Administration of R-beta-hydroxybutyrate and related compounds in humans | AXCESS GLOBAL SCIENCES, LLC (US) | 2024-10-08 | — | — | US | claimed |
| EP-3445355-B1 | BETA-HYDROXYBUTYRATE FOR USE IN NON-THERAPEUTIC METHODS OF CONTROLLING WEIGHT LOSS AND KETOTIS | AXCESS GLOBAL SCIENCES LLC (US) | 2023-11-29 | — | — | EP | claimed |
| CN-115835786-A | Enantiomerically pure R-beta-hydroxybutyrate mixed salt-acid compositions | 阿克塞斯全球科学有限责任公司 | 2023-03-21 | — | — | CN | claimed |
| WO-2023278881-A1 | ADMINISTRATION OF R-BETA-HYDROXYBUTYRATE AND RELATED COMPOUNDS IN HUMANS | Keto Patent Group, Inc. (US) | 2023-01-05 | — | — | WO | claimed |
| EP-4099848-A1 | ENANTIOMERICALLY PURE R-BETA-HYDROXYBUTYRATE MIXED SALT-ACID COMPOSITIONS | Axcess Global Sciences, LLC (US) | 2022-12-14 | — | — | EP | claimed |
| CN-115251375-A | (R) -3-hydroxybutyric acid ketonic product and preparation method thereof | 珠海麦得发生物科技股份有限公司 | 2022-11-01 | — | — | CN | claimed |
| US-11419836-B2 | Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions | AXCESS GLOBAL SCIENCES, LLC (US) | 2022-08-23 | — | — | US | claimed |
| CN-110035991-B | Preparation of (R) -3-hydroxybutyric acid or its salt by one-step fermentation | NNB营养品美国有限公司 | 2022-06-17 | — | — | CN | claimed |
| US-11241401-B2 | Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions | AXCESS GLOBAL SCIENCES, LLC (US) | 2022-02-08 | — | — | US | claimed |
| US-20210244690-A1 | ENANTIOMERICALLY PURE R-BETA-HYDROXYBUTYRATE MIXED SALT-ACID COMPOSITIONS | AXCESS GLOBAL SCIENCES, LLC | 2021-08-12 | — | — | US | claimed |
| US-20210177786-A1 | RACEMIC AND NEAR RACEMIC BETA-HYDROXYBUTYRATE MIXED SALT-ACID COMPOSITIONS | AXCESS GLOBAL SCIENCES, LLC | 2021-06-17 | — | — | US | claimed |
| US-10973792-B2 | Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use | AXCESS GLOBAL SCIENCES, LLC (US) | 2021-04-13 | — | — | US | claimed |
| WO-2020167690-A1 | RACEMIC BETA-HYDROXYBUTYRATE MIXED SALT-ACID COMPOSITIONS AND METHODS OF USE | ACCESS GLOBAL SCIENCES, LLC (US) | 2020-08-20 | — | — | WO | claimed |
| US-20200253909-A1 | RACEMIC BETA-HYDROXYBUTYRATE MIXED SALT-ACID COMPOSITIONS AND METHODS OF USE | AXCESS GLOBAL SCIENCES, LLC | 2020-08-13 | — | — | US | claimed |
| CN-110035991-A | One-step fermentation prepares (R) -3-hydroxybutyrate or its salt | NNB营养品美国有限公司 | 2019-07-19 | — | — | CN | claimed |
| EP-3507272-A1 | PREPARATION OF (R)-3-HYDROXYBUTYRIC ACID OR ITS SALTS BY ONE-STEP FERMENTATION | NNB Nutrition USA, LLC (US) | 2019-07-10 | — | — | EP | claimed |
| WO-2018187324-A1 | PREPARATION OF (R)-3-HYDROXYBUTYRIC ACID OR ITS SALTS BY ONE-STEP FERMENTATION | NNB Nutrition USA, LLC (US) | 2018-10-11 | — | — | WO | claimed |
| US-20180282767-A1 | PREPARATION OF (R)-3-HYDROXYBUTYRIC ACID OR ITS SALTS BY ONE-STEP FERMENTATION | NANJING NUTRABUILDING BIO-TECH CO., LTD. (CN) | 2018-10-04 | — | — | US | claimed |
| CN-107162893-A | (R) synthesis technique of 3 hydroxybutyric acids and its salt | 洛阳华荣生物技术有限公司 | 2017-09-15 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11419836-B2 | Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions | HBB, SCNN1B, SCN2B | CA2 876/4885CA4 1250/4885SLC22A16 187/4885 |
| US-20200253909-A1 | RACEMIC BETA-HYDROXYBUTYRATE MIXED SALT-ACID COMPOSITIONS AND METHODS OF USE | SCNN1B, HBB, SLC16A1 | CA2 296/4885CA4 571/4885SLC22A16 142/4885 |
| US-20210177786-A1 | RACEMIC AND NEAR RACEMIC BETA-HYDROXYBUTYRATE MIXED SALT-ACID COMPOSITIONS | HBB, SCNN1B, SCN2B | CA2 876/4885CA4 1250/4885SLC22A16 187/4885 |
| US-11241401-B2 | Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions | SLC16A1, SCNN1B, HBB | CA2 226/4885CA4 432/4885SLC22A16 137/4885 |
| US-20210244690-A1 | ENANTIOMERICALLY PURE R-BETA-HYDROXYBUTYRATE MIXED SALT-ACID COMPOSITIONS | SLC16A1, SCNN1B, HBB | CA2 226/4885CA4 432/4885SLC22A16 137/4885 |
| US-10973792-B2 | Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use | SCNN1B, HBB, SLC16A1 | CA2 296/4885CA4 571/4885SLC22A16 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.