Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17687823 | 0.84 | DYRK1A (0.34) | CDK8BRD4DYRK1ADYRK2DYRK1B | |
| SCHEMBL19463373 | 0.82 | CDK8 (0.38) | CDK8BRD4DYRK1ADYRK2DYRK1B | |
| SCHEMBL17687890 | 0.81 | ADORA2A (0.40) | BRD4DYRK1A | |
| SCHEMBL17687913 | 0.81 | ADORA2A (0.40) | BRD4DYRK1A | |
| SCHEMBL19471478 | 0.81 | ADORA2A (0.40) | BRD4DYRK1A | |
| SCHEMBL19463827 | 0.80 | KMO (0.35) | KMOMTOR | |
| SCHEMBL22528205 | 0.79 | HDAC4 (0.42) | CDK8BRD4HDAC4MEF2DPRKDC | |
| SCHEMBL16180162 | 0.78 | NPC1 (0.42) | CDK8BRD4DYRK1ADYRK2DYRK1B | |
| SCHEMBL17687811 | 0.78 | SCD5 (0.39) | TRIM24TRIM33GABRG2GABRB3GABRA5 | |
| SCHEMBL17687808 | 0.78 | SCD5 (0.39) | TRIM24TRIM33GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200325154-A1 | ANTIBACTERIAL BIAROMATIC DERIVATIVES WITH OXETANE-3-YLOXY SUBSTITUTION | ACTELION PHARMACEUTICALS LTD (CH) | 2020-10-15 | — | — | US | disclosed |
| EP-3442970-A1 | ANTIBACTERIAL BIAROMATIC DERIVATIVES WITH OXETANE-3-YLOXY SUBSTITUTION | Idorsia Pharmaceuticals Ltd (CH) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017179002-A1 | ANTIBACTERIAL BIAROMATIC DERIVATIVES WITH OXETANE-3-YLOXY SUBSTITUTION | ACTELION PHARMACEUTICALS LTD (CH) | 2017-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200325154-A1 | ANTIBACTERIAL BIAROMATIC DERIVATIVES WITH OXETANE-3-YLOXY SUBSTITUTION | MT-CO3, UQCRC1, MT-ND3 | CDK8 3978/4885BRD4 1716/4885DYRK1A 3955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.