Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 5/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19463138 | 0.82 | CDK8 (0.35) | CDK8AXLBRD4DYRK1ADYRK2 | |
| SCHEMBL15748363 | 0.81 | ENPP2 (0.38) | CDK8KDM1AAXLBRD4GRM5 | |
| SCHEMBL22528205 | 0.80 | HDAC4 (0.42) | CDK8BRD4HDAC4MEF2DMAOB | |
| SCHEMBL22528207 | 0.78 | SLC6A2 (0.42) | CDK8BRD4MTORKMOPRKDC | |
| SCHEMBL18114419 | 0.77 | SRC (0.46) | HDAC4MEF2DMAOB | |
| SCHEMBL12641894 | 0.73 | CDK8 (0.47) | CDK8KDM1AAXLBRD4CYP11B1 | |
| SCHEMBL31327369 | 0.72 | CDK8 (0.58) | CDK8AXLBRD4DYRK1ADYRK2 | |
| SCHEMBL18949396 | 0.71 | KDM1A (0.66) | KDM1AMAOB | |
| SCHEMBL28376659 | 0.70 | ALDH1A1 (0.58) | — | |
| SCHEMBL12641896 | 0.70 | CYP2A6 (0.54) | CDK8KDM1AAXLBRD4DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442970-A1 | ANTIBACTERIAL BIAROMATIC DERIVATIVES WITH OXETANE-3-YLOXY SUBSTITUTION | Idorsia Pharmaceuticals Ltd (CH) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017179002-A1 | ANTIBACTERIAL BIAROMATIC DERIVATIVES WITH OXETANE-3-YLOXY SUBSTITUTION | ACTELION PHARMACEUTICALS LTD (CH) | 2017-10-19 | — | — | WO | disclosed |