Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.69 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.61 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12642617 | 0.90 | ALDH1A1 (0.65) | KDM4EALDH1A1GAASIGMAR1CYP1A2 | |
| SCHEMBL10511765 | 0.88 | HTR7 (0.64) | KDM4EALDH1A1GAASIGMAR1CYP1A2 | |
| SCHEMBL9727092 | 0.86 | DRD4 (0.63) | KDM4EALDH1A1GAASIGMAR1MCHR1 | |
| SCHEMBL694949 | 0.81 | SIGMAR1 (0.82) | SIGMAR1TMEM97SLC6A12MCHR1CYP1A2 | |
| SCHEMBL6213917 | 0.81 | GAA (0.70) | KDM4EALDH1A1GAASIGMAR1TSHR | |
| SCHEMBL31736417 | 0.80 | MCHR1 (0.77) | SIGMAR1TMEM97SLC6A12MCHR1CYP1A2 | |
| SCHEMBL2425554 | 0.80 | SIGMAR1 (0.78) | SIGMAR1TMEM97SLC6A12MCHR1CYP1A2 | |
| SCHEMBL825926 | 0.79 | RAB9A (0.84) | KDM4EALDH1A1GAACYP1A2CYP3A4 | |
| SCHEMBL61848 | 0.79 | TMEM97 (0.83) | SIGMAR1TMEM97SLC6A12MCHR1CYP1A2 | |
| SCHEMBL5124505 | 0.79 | SIGMAR1 (0.81) | SIGMAR1L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10577360-B2 | Arylamide derivatives having multimodal activity against pain | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-03-03 | — | — | US | disclosed |
| US-10577360-B2 | Arylamide derivatives having multimodal activity against pain | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-03-03 | — | — | US | disclosed |
| US-20190127357-A1 | ARYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-05-02 | — | — | US | disclosed |
| US-20190127357-A1 | ARYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-05-02 | — | — | US | disclosed |
| EP-3442960-A1 | ARYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017178510-A1 | ARYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-10-19 | — | — | WO | disclosed |
| WO-2017178510-A1 | ARYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10577360-B2 | Arylamide derivatives having multimodal activity against pain | OPRD1, TRPV1, OPRL1 | KDM4E 2326/4885ALDH1A1 901/4885GAA 1675/4885 |
| US-20190127357-A1 | ARYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | OPRD1, TRPV1, OPRL1 | KDM4E 2326/4885ALDH1A1 901/4885GAA 1675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.