SCHEMBL19469366

SCHEMBL19469366

O=C(C(Cl)CCc1ccccc1)C(Cl)CCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 1/20 0.49
▸ TSHR P16473 1/20 0.49
▸ KEAP1 Q14145 1/20 0.48
▸ ANPEP P15144 2/20 0.47
▸ ERAP1 Q9NZ08 2/20 0.47
▸ MEN1 O00255 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ ERAP2 Q6P179 1/20 0.47
▸ NPC1 O15118 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ AKR1B1 P15121 1/20 0.46
▸ PPARG P37231 1/20 0.46
▸ PPARA Q07869 1/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ HTT P42858 1/20 0.46
▸ HPGD P15428 1/20 0.46
▸ ACP3 P15309 1/20 0.46
▸ HDAC3 O15379 1/20 0.45
▸ MAPK1 P28482 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7372199 0.88 PPARG (0.50) CNR2TSHRKEAP1ANPEPERAP1
SCHEMBL3433828 0.88 PPARG (0.50) CNR2TSHRKEAP1ANPEPERAP1
SCHEMBL9753996 0.86 CNR2 (0.47) CNR2TSHRKEAP1ANPEPERAP1
SCHEMBL29223822 0.80 TSHR (0.54) CNR2TSHRMEN1KMT2ATDP1
P-Toluenesulfonamide SCHEMBL4747609 0.80 ALDH1A1 (0.50) TSHRALDH1A1
SCHEMBL12266041 0.78 METAP2 (0.49) CNR2TSHRANPEPERAP1KMT2A
SCHEMBL11823662 0.77 MMP12 (0.58) TSHRHTTFFAR1
SCHEMBL4160692 0.77 TSHR (0.47) CNR2TSHRMEN1KMT2ANPC1
SCHEMBL6462807 0.76 MMP12 (0.53) CNR2TSHRKEAP1AKR1B1SMN1; SMN2
SCHEMBL27884209 0.76 GRIK1 (0.54) KEAP1KMT2ANPC1RAB9ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3903783-B1 THERAPEUTIC AGENT FOR RNA VIRAL INFECTION OBTAINED BY COMBINING A PYRAZINE DERIVATIVE AND A COMPOUND INCREASING THE AMOUNT OF PYRAZINE DERIVATIVE RIBOSE TRIPHOSPHATE IN A CELL. FUJIFILM TOYAMA CHEMICAL CO LTD (JP) 2025-03-05 — — EP disclosed
CN-119213024-A HMPV antibodies and uses thereof 佐治亚大学研究基金会有限公司 2024-12-27 — — CN disclosed
CN-117286113-A Application of recombinant trypsin in influenza vaccine production of cell culture system without animal source component 上海生物制品研究所有限责任公司 2023-12-26 — — CN disclosed
CN-117222424-A Alpha-1-antitrypsin (AAT) for the treatment and/or prophylaxis of neurological disorders 阿格罗尼克斯股份有限公司 2023-12-12 — — CN disclosed
CN-116782920-A Neuropilin and angiotensin converting enzyme 2 fusion peptides for the treatment of viral infections 常青树治疗公司 2023-09-19 — — CN disclosed
US-20230201238-A1 THERAPEUTIC AGENT FOR AN RNA VIRUS INFECTION COMPRISING A COMBINATION OF A PYRAZINE DERIVATIVE AND A THIOPURINE DERIVATIVE FUJIFILM TOYAMA CHEMICAL CO., LTD. (JP) 2023-06-29 — — US disclosed
EP-4159215-A1 THERAPEUTIC AGENT FOR RNA VIRAL INFECTION OBTAINED BY COMBINING PYRAZINE DERIVATIVE AND THIOPURINE DERIVATIVE FUJIFILM Toyama Chemical Co., Ltd. (JP) 2023-04-05 — — EP disclosed
US-20220096468-A1 Therapeutic agent for RNA viral infection comprising a combination of pyrazine derivative and compound which increases amount of pyrazine derivative ribose triphosphate in cell FUJIFILM TOYAMA CHEMICAL CO., LTD. (JP) 2022-03-31 — — US disclosed
US-20180003712-A1 KIT FOR DETECTING VIRUS KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2018-01-04 — — US disclosed
EP-3244211-A1 KIT FOR DETECTING VIRUS Huvet Bio, Inc. (KR) 2017-11-15 — — EP disclosed
EP-3244210-A1 KIT FOR DETECTING VIRUS Huvet Bio, Inc. (KR) 2017-11-15 — — EP disclosed
US-20170307612-A1 KIT FOR DETECTING VIRUS HUVET BIO, INC. (KR) 2017-10-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220096468-A1 Therapeutic agent for RNA viral infection comprising a combination of pyrazine derivative and compound which increases amount of pyrazine derivative ribose triphosphate in cell EIF2AK2, NSUN2, ZC3HAV1 CNR2 4236/4885TSHR 4231/4885KEAP1 1524/4885
US-20230201238-A1 THERAPEUTIC AGENT FOR AN RNA VIRUS INFECTION COMPRISING A COMBINATION OF A PYRAZINE DERIVATIVE AND A THIOPURINE DERIVATIVE NSUN2, EIF2AK2, TPMT CNR2 4055/4885TSHR 3361/4885KEAP1 2911/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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