Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | ANPEP | P15144 | 2/20 | 0.46 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19469366 | 0.86 | CNR2 (0.49) | CNR2TSHRKEAP1ANPEPERAP1 | |
| SCHEMBL3433828 | 0.86 | PPARG (0.50) | CNR2TSHRKEAP1ANPEPERAP1 | |
| SCHEMBL7372199 | 0.86 | PPARG (0.50) | CNR2TSHRKEAP1ANPEPERAP1 | |
| SCHEMBL28213570 | 0.82 | MMP8 (0.51) | CNR2TSHRKEAP1ANPEPERAP1 | |
| SCHEMBL11859970 | 0.79 | CYP1A2 (0.54) | KEAP1NPC1RAB9AAKR1B1ALDH1A1 | |
| SCHEMBL6054519 | 0.79 | CYP1A2 (0.54) | KEAP1NPC1RAB9AAKR1B1ALDH1A1 | |
| SCHEMBL3710024 | 0.78 | TSHR (0.64) | CNR2TSHRKEAP1MEN1KMT2A | |
| SCHEMBL29223822 | 0.78 | TSHR (0.54) | CNR2TSHRMEN1KMT2ATDP1 | |
| SCHEMBL12266041 | 0.77 | METAP2 (0.49) | CNR2TSHRANPEPERAP1KMT2A | |
| SCHEMBL11823662 | 0.76 | MMP12 (0.58) | TSHRHTTFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5032588-A | Non-steroidal antiinflammatory | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | disclosed |