Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 10/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16571392 | 0.89 | PTPN11 (0.42) | PTPN11NUDT1SYKCCNCCDK8 | |
| SCHEMBL16571148 | 0.77 | NUDT1 (0.43) | PTPN11NUDT1SYKCCNCCDK8 | |
| SCHEMBL16570776 | 0.76 | XDH (0.36) | NUDT1SYKCCNCCDK8PARP10 | |
| SCHEMBL16571121 | 0.75 | XDH (0.39) | PTPN11NUDT1ALOX15 | |
| SCHEMBL16571097 | 0.74 | CCNC (0.46) | PTPN11NUDT1SYKCCNCCDK8 | |
| SCHEMBL16571417 | 0.72 | XDH (0.38) | PTPN11ALOX15 | |
| SCHEMBL16570969 | 0.71 | LRRK2 (0.40) | PTPN11NUDT1SYKALOX15 | |
| SCHEMBL16571406 | 0.70 | PDE4A (0.41) | NUDT1SYKALOX15 | |
| SCHEMBL16570967 | 0.70 | ALOX15 (0.35) | PTPN11NUDT1SYKALOX15 | |
| SCHEMBL16571383 | 0.69 | ALOX15 (0.43) | PTPN11NUDT1SYKALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | disclosed |