Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PRF1 | P14222 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4724309 | 0.87 | KDM4E (0.48) | ATAD2ALDH1A1KDM4EHPGDCRBN | |
| SCHEMBL1952399 | 0.87 | ALDH1A1 (0.57) | ATAD2ALDH1A1KDM4EHPGDCRBN | |
| SCHEMBL2504791 | 0.84 | KDM4E (0.52) | ATAD2ALDH1A1KDM4EHPGDCRBN | |
| SCHEMBL1950172 | 0.84 | CASP1 (0.49) | ATAD2CASP1CASP7HSD17B10GRM5 | |
| SCHEMBL28846879 | 0.83 | KDM4E (0.44) | ATAD2ALDH1A1KDM4EHPGDCRBN | |
| SCHEMBL1026421 | 0.81 | GRM5 (0.44) | KDM4EHSD17B10PRF1MAPTGRM5 | |
| SCHEMBL3388515 | 0.81 | KDM4E (0.51) | ALDH1A1KDM4EHPGDCRBNCASP1 | |
| SCHEMBL28611949 | 0.80 | KDM4E (0.45) | ALDH1A1KDM4EHPGDCRBNCASP1 | |
| SCHEMBL28612494 | 0.80 | PARP1 (0.48) | ALDH1A1KDM4EHPGDCRBNHSD17B10 | |
| SCHEMBL31409528 | 0.80 | ADAM17 (0.48) | ALDH1A1KDM4EHPGDCRBNHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438044-B1 | COMPOUNDS | JAPAN TOBACCO INC (JP) | 2019-01-23 | — | — | EP | disclosed |
| US-8399481-B2 | Compounds | XENTION LTD (GB) | 2013-03-19 | — | — | US | disclosed |
| EP-2438044-A1 | COMPOUNDS | Xention Limited (GB) | 2012-04-11 | — | — | EP | disclosed |
| US-20110136859-A1 | Compounds | XENTION LTD. (GB) | 2011-06-09 | — | — | US | disclosed |
| WO-2010139953-A1 | COMPOUNDS | XENTION LIMITED (GB) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136859-A1 | Compounds | CYP2C8, CYP3A7, CYP2A7 | ATAD2 4425/4885ALDH1A1 1680/4885KDM4E 3464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.