SCHEMBL19520239

SCHEMBL19520239

O=C(NCCO)Nc1cccc(C(F)(F)F)n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CLK4 Q9HAZ1 12/20 0.52
▸ GSK3A P49840 9/20 0.52
▸ GSK3B P49841 9/20 0.52
▸ SRPK1 Q96SB4 4/20 0.52
▸ HIPK4 Q8NE63 4/20 0.52
▸ STK3 Q13188 4/20 0.52
▸ AURKB Q96GD4 4/20 0.52
▸ MAP4K4 O95819 3/20 0.52
▸ CSNK2A1 P68400 3/20 0.52
▸ RPS6KA3 P51812 3/20 0.52
▸ MAPKAPK2 P49137 3/20 0.52
▸ CSNK1G3 Q9Y6M4 3/20 0.52
▸ CDK2 P24941 3/20 0.52
▸ PIM3 Q86V86 3/20 0.52
▸ FLT3 P36888 3/20 0.52
▸ PRKD3 O94806 3/20 0.52
▸ CLK2 P49760 3/20 0.52
▸ PBK Q96KB5 3/20 0.52
▸ PLK3 Q9H4B4 2/20 0.52
▸ DYRK4 Q9NR20 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29128671 0.79 CLK4 (0.53) CLK4GSK3AGSK3BSRPK1HIPK4
SCHEMBL21723559 0.79 IDH2 (0.56) CLK4GSK3AGSK3BSRPK1HIPK4
SCHEMBL12506975 0.78 CLK4 (0.51) CLK4GSK3AGSK3BSRPK1HIPK4
SCHEMBL2635287 0.77 TAS2R14 (0.57) CLK4GSK3AGSK3BSRPK1HIPK4
SCHEMBL29128691 0.77 CLK4 (0.51) CLK4GSK3AGSK3BSRPK1HIPK4
SCHEMBL5031654 0.75 P2RX7 (0.53) CLK4GSK3AGSK3BSRPK1HIPK4
SCHEMBL13170010 0.75 KDM4E (0.56) CLK4GSK3AGSK3BSRPK1HIPK4
SCHEMBL29640129 0.75 P2RX7 (0.53) CLK4GSK3AGSK3BSRPK1HIPK4
SCHEMBL18425134 0.75 ACVR1 (0.49) CLK4GSK3AGSK3BSRPK1HIPK4
SCHEMBL10327562 0.75 TAS2R14 (0.49) CLK4GSK3AGSK3BSRPK1HIPK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190330180-A1 PROCESS FOR THE PREPARATION OF HERBICIDAL PYRIDINYLIMIDAZOLONE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2019-10-31 — — US disclosed
WO-2017186624-A1 PROCESS FOR THE PREPARATION OF HERBICIDAL PYRIDINYLIMIDAZOLONE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2017-11-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190330180-A1 PROCESS FOR THE PREPARATION OF HERBICIDAL PYRIDINYLIMIDAZOLONE COMPOUNDS DDT, PDXK, CYP4F3 CLK4 2136/4885GSK3A 2708/4885GSK3B 2199/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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