Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17544553 | 0.86 | MMP13 (0.40) | CES2GNRHRTP53MAPT | |
| SCHEMBL17544963 | 0.84 | P2RX3 (0.41) | POLBCES2ENPP2TP53MAPT | |
| SCHEMBL17683831 | 0.79 | MMP13 (0.40) | CES2GNRHRTP53 | |
| SCHEMBL17544838 | 0.79 | AGTR1 (0.36) | ENPP2GNRHRTP53MAPTP2RX3 | |
| SCHEMBL17544481 | 0.75 | P2RX3 (0.39) | POLBENPP2TP53MAPTP2RX3 | |
| SCHEMBL17544846 | 0.73 | MMP13 (0.42) | POLBCES2MEN1KMT2ATP53 | |
| SCHEMBL17544535 | 0.72 | PDE6D (0.42) | CES2TP53 | |
| SCHEMBL17680451 | 0.72 | GNRHR (0.38) | POLBENPP2GNRHRTP53MAPT | |
| SCHEMBL17544571 | 0.72 | RAB9A (0.37) | ENPP2ALOX5AP | |
| SCHEMBL17544934 | 0.71 | TP53 (0.41) | POLBCES2TP53MAPTP2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9802941-B2 | Compounds and methods for inhibiting histone demethylases | GILEAD SCIENCES, INC. (US) | 2017-10-31 | — | — | US | disclosed |