SCHEMBL195408

SCHEMBL195408

Cc1cc(C#N)cc(C(=O)NC(C)C2CC2)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.61

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 3/20 0.39
DHODH Q02127 2/20 0.38
IDO1 P14902 2/20 0.36
MALT1 Q9UDY8 2/20 0.35
NAMPT P43490 2/20 0.34
GPR6 P46095 1/20 0.34
CNR1 P21554 2/20 0.34
CNR2 P34972 2/20 0.34
RIPK1 Q13546 1/20 0.34
GCK P35557 1/20 0.34
KCNH2 Q12809 1/20 0.34
TYK2 P29597 1/20 0.33
CCR8 P51685 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29416635 1.00 EGLN1 (0.39) EGLN1DHODHIDO1MALT1NAMPT
SCHEMBL195661 0.94 IDO1 (0.36) EGLN1DHODHIDO1NAMPTGPR6
SCHEMBL29416604 0.94 IDO1 (0.36) EGLN1DHODHIDO1NAMPTGPR6
SCHEMBL29416585 0.93 IDO1 (0.36) EGLN1DHODHIDO1MALT1NAMPT
SCHEMBL516589 0.93 IDO1 (0.36) EGLN1DHODHIDO1MALT1NAMPT
SCHEMBL29416550 0.91 DHODH (0.40) DHODHIDO1MALT1NAMPTCNR1
SCHEMBL195314 0.91 DHODH (0.40) DHODHIDO1MALT1NAMPTCNR1
SCHEMBL30078383 0.91 DHODH (0.41) EGLN1DHODHMALT1GCKKCNH2
SCHEMBL563173 0.91 DHODH (0.41) EGLN1DHODHMALT1GCKKCNH2
SCHEMBL11893160 0.88 DHODH (0.40) EGLN1DHODHMALT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110224075-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds BASF SE (DE) 2011-09-15 US claimed
US-20110118212-A1 Pestcidal active mixtures comprising isoxazoline compounds I BASF SE (DE) 2011-05-19 US claimed
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US claimed
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS ANNAN ISSAC BILLY 2009-03-19 US claimed
CN-114573573-A Antiparasitic isoxazoline compounds, long-acting injectable formulations containing them, methods and uses thereof 勃林格殷格翰动物保健美国公司 2022-06-03 CN disclosed
CN-109068651-B Antiparasitic isoxazoline compounds, long-acting injectable formulations containing them, methods and uses thereof 勃林格殷格翰动物保健美国公司 2022-03-01 CN disclosed
US-10231455-B2 Pesticidal active mixtures comprising isoxazoline compounds I BASF SE (DE) 2019-03-19 US disclosed
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2018-06-21 US disclosed
US-20180007904-A1 Pesticidal Active Mixtures Comprising Isoxazoline Compounds I BASF SE (DE) 2018-01-11 US disclosed
US-9826737-B2 Solid formulations of carboxamide arthropodicides E I DU PONT DE NEMOURS AND COMPANY (US) 2017-11-28 US disclosed
US-20170215419-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE E I DUPONT DE NEMOURS AND COMPANY 2017-08-03 US disclosed
US-9332756-B2 Liquid formulations of carboxamide arthropodicides E I DU PONT DE NEMOURS AND COMPANY (US) 2016-05-10 US disclosed
EP-1968382-B1 LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES DU PONT (US) 2009-09-16 EP disclosed
EP-2094092-A1 LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2009-09-02 EP disclosed
US-20090133318-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2009-05-28 US disclosed
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS ANNAN ISSAC BILLY 2009-03-19 US disclosed
WO-2009002856-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-12-31 WO disclosed
US-20080305093-A1 Liquid Formulations of Carboxamide Arthropodicides FMC IP TECHNOLOGY GMBH (CH) 2008-12-11 US disclosed
WO-2008069990-A1 LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-06-12 WO disclosed
WO-2008021152-A2 AGRONOMIC METHOD E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090133318-A1 Anthranilamide insecticides C3AR1, C5, C1S EGLN1 1750/4885DHODH 1809/4885IDO1 143/4885
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS NASP, CPS1, CYP11A1 EGLN1 668/4885DHODH 313/4885IDO1 460/4885
US-20080305093-A1 Liquid Formulations of Carboxamide Arthropodicides FAAH, C9, FAAH2 EGLN1 1174/4885DHODH 3010/4885IDO1 70/4885
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE AADAC, ABL2, API5 EGLN1 691/4885DHODH 1157/4885IDO1 132/4885
US-20110224075-A1 Pesticidal Active Mixtures Comprising Aminothiazoline Compounds CBR3, AOC3, MT-CO3 EGLN1 2941/4885DHODH 2236/4885IDO1 428/4885
US-20110118212-A1 Pestcidal active mixtures comprising isoxazoline compounds I CHRM3, CHRM5, CHRM1 EGLN1 3203/4885DHODH 4306/4885IDO1 705/4885
US-20180007904-A1 Pesticidal Active Mixtures Comprising Isoxazoline Compounds I CHRM3, CHRM5, CACNA1C EGLN1 3214/4885DHODH 4267/4885IDO1 585/4885
US-10231455-B2 Pesticidal active mixtures comprising isoxazoline compounds I CHRM3, CHRM5, CACNA1C EGLN1 3214/4885DHODH 4267/4885IDO1 585/4885
US-20170215419-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE AADAC, ABL2, API5 EGLN1 691/4885DHODH 1157/4885IDO1 132/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.