Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19554215 | 0.88 | SMN1; SMN2 (0.44) | KMOGRM5SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL19554254 | 0.87 | HDAC3 (0.40) | HDAC3GRM5HPGDS | |
| SCHEMBL19575437 | 0.84 | KMO (0.38) | KMOGRM5SCN9ACNR2 | |
| SCHEMBL19554238 | 0.79 | SERPINE1 (0.45) | GRM5SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL19554182 | 0.79 | NPC1 (0.42) | SMN1; SMN2 | |
| SCHEMBL19554150 | 0.77 | KCNK2 (0.52) | HDAC3KDM4E | |
| SCHEMBL19555237 | 0.75 | NPC1 (0.57) | HDAC3SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL19554194 | 0.75 | PDE5A (0.39) | GRM5 | |
| SCHEMBL19575819 | 0.72 | JAK2 (0.33) | GRM5 | |
| SCHEMBL19554093 | 0.71 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EALDH1A1HPGDPYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | claimed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |
| WO-2017192304-A1 | ARYLCARBOXAMIDES AND USES THEREOF | INCEPTION 1, INC. (US) | 2017-11-09 | — | — | WO | disclosed |