Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18500481 | 0.84 | ALDH1A1 (0.39) | NPC1RAB9ASMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL16490967 | 0.80 | RAB9A (0.32) | NPC1RAB9APKMSMN1; SMN2TP53 | |
| SCHEMBL4672097 | 0.73 | DHODH (0.41) | NPC1RAB9ASMN1; SMN2L3MBTL1ADORA3 | |
| SCHEMBL2611112 | 0.73 | PTGS2 (0.46) | NPC1RAB9ASMN1; SMN2ADORA3LMNA | |
| SCHEMBL2611117 | 0.72 | GSK3A (0.47) | RAB9AL3MBTL1MAPTALDH1A1KDM4E | |
| SCHEMBL8301872 | 0.72 | ALDH1A1 (0.51) | PKMTP53ADORA3MAPTALDH1A1 | |
| SCHEMBL18811742 | 0.71 | CA1 (0.43) | SMN1; SMN2L3MBTL1TP53LMNAMAPT | |
| SCHEMBL18504888 | 0.70 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL18500482 | 0.69 | KCNN4 (0.34) | L3MBTL1LMNAMAPTKDM4E | |
| SCHEMBL4672091 | 0.68 | ALDH1A1 (0.47) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507227-A1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | Rigel Pharmaceuticals, Inc. (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068898-A1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS, INC. (US) | 2011-06-09 | — | — | WO | disclosed |