Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672097 | 0.80 | DHODH (0.41) | ALDH1A1HTTGAAADORA3TSHR | |
| SCHEMBL2611112 | 0.80 | PTGS2 (0.46) | ALDH1A1GSK3AGSK3BGAAIDO1 | |
| SCHEMBL18504503 | 0.80 | CYP1A2 (0.56) | ALDH1A1GAAIDO1TDO2ADORA3 | |
| SCHEMBL18504499 | 0.80 | IDO1 (0.49) | ALDH1A1HTTGAAIDO1TDO2 | |
| SCHEMBL18504528 | 0.78 | FAAH (0.46) | ALDH1A1HTTIDO1TDO2NFE2L2 | |
| SCHEMBL1942309 | 0.78 | ADRA2C (0.45) | ALDH1A1TSHRMAPT | |
| SCHEMBL18503912 | 0.78 | IDO1 (0.50) | ALDH1A1HTTGAAIDO1TDO2 | |
| SCHEMBL16490945 | 0.77 | CYP1A2 (0.41) | ALDH1A1HTTGAAIDO1TDO2 | |
| SCHEMBL15790778 | 0.77 | RAB9A (0.55) | ALDH1A1HTTTSHRMAPK1NPSR1 | |
| SCHEMBL2611117 | 0.76 | GSK3A (0.47) | ALDH1A1GSK3AGSK3BGAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11129819-B2 | Fumarate analogs and uses thereof | RIGEL PHARMACEUTICALS, INC. (US) | 2021-09-28 | — | — | US | disclosed |
| US-20200155531-A1 | Fumarate Analogs and Uses Thereof | MIDCAP FINANCIAL TRUST | 2020-05-21 | — | — | US | disclosed |
| US-7166603-B2 | Dihydropyrimidone inhibitors of calcium channel function | BRISTOL-MYERS SQUIBB CO. (US) | 2007-01-23 | — | — | US | disclosed |
| WO-2005009392-A2 | DIHYDROPYRIMIDONE INHIBITORS OF CALCIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155531-A1 | Fumarate Analogs and Uses Thereof | FH, GLS, FPGS | ALDH1A1 817/4885HTT 1194/4885GSK3A 1709/4885 |
| US-11129819-B2 | Fumarate analogs and uses thereof | FH, GLS, FPGS | ALDH1A1 817/4885HTT 1194/4885GSK3A 1709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.