Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675102 | 0.80 | ALDH1A1 (0.42) | ALDH1A1HPGDMAPK1ATMSMN1; SMN2 | |
| SCHEMBL2611112 | 0.75 | PTGS2 (0.46) | ALDH1A1SMN1; SMN2HSD17B10PTGS2POLB | |
| SCHEMBL4670479 | 0.75 | ALDH1A1 (0.39) | ALDH1A1HPGDMAPK1ATMSMN1; SMN2 | |
| SCHEMBL8301872 | 0.74 | ALDH1A1 (0.51) | ALDH1A1HPGDMAPK1TSHRGAA | |
| SCHEMBL4670084 | 0.72 | ROCK2 (0.56) | ALDH1A1HPGDMAPK1ATMMEN1 | |
| SCHEMBL4670468 | 0.71 | PARP15 (0.42) | ALDH1A1MAPK1ATMMEN1KMT2A | |
| SCHEMBL4673352 | 0.71 | MAPK1 (0.50) | ALDH1A1HPGDMAPK1ATMMEN1 | |
| SCHEMBL4670421 | 0.71 | PARP10 (0.42) | ALDH1A1MAPK1ATMKDM4EMEN1 | |
| SCHEMBL2611117 | 0.71 | GSK3A (0.47) | ALDH1A1ATMKDM4EPTGS2GAA | |
| SCHEMBL4673552 | 0.70 | MAPK1 (0.49) | ALDH1A1HPGDMAPK1ATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054881-B1 | NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS | BAYER CORP (US) | 2008-07-30 | — | — | EP | disclosed |
| US-6903218-B2 | Sulfonamide substituted chroman derivatives | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-06-07 | — | — | US | disclosed |
| US-6051586-A | HYPOGLYCEMIC AGENTS; ANTIDIABETIC AGENTS | BAYER CORPORATION (US) | 2000-04-18 | — | — | US | disclosed |