Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29248774 | 0.75 | PTGS2 (0.48) | PTGS2LCKPDE4BNR1H2NR1H3 | |
| SCHEMBL794276 | 0.75 | PTGS2 (0.69) | PTGS2LCKPDE4BNR1H2NR1H3 | |
| SCHEMBL3876865 | 0.75 | PTGS2 (0.44) | PTGS2LCKPDE4BNR1H2NR1H3 | |
| SCHEMBL14777408 | 0.73 | NR1H2 (0.53) | PTGS2NR1H2NR1H3HTTKMT2A | |
| SCHEMBL6310937 | 0.73 | LCK (0.57) | PTGS2LCKPDE4BNR1H2NR1H3 | |
| SCHEMBL29644690 | 0.73 | PTGS2 (0.67) | PTGS2PDE4BNR1H2NR1H3ALDH1A1 | |
| SCHEMBL29644739 | 0.73 | LCK (0.57) | LCKNR1H2NR1H3LMNAHTT | |
| SCHEMBL14410649 | 0.70 | POLB (0.48) | MAPTLMNAHTTKMT2AGAA | |
| SCHEMBL14560459 | 0.70 | NR1H2 (0.69) | PTGS2LCKPDE4BNR1H2NR1H3 | |
| SCHEMBL29644717 | 0.70 | PTGS2 (0.44) | PTGS2LCKPDE4BNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210220331-A1 | INHIBITORS OF IRES-MEDIATED PROTEIN SYNTHESIS | THE UNITED STATES GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2021-07-22 | — | — | US | disclosed |
| WO-2017192665-A1 | INHIBITORS OF IRES-MEDIATED PROTEIN SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210220331-A1 | INHIBITORS OF IRES-MEDIATED PROTEIN SYNTHESIS | EIF4EBP1, EIF4E, EIF2A | PTGS2 2846/4885LCK 1130/4885PDE4B 4432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.