Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ABAT | P80404 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12015389 | 0.86 | ESR2 (0.38) | DRD2DRD4DRD3MCHR1ESR1 | |
| SCHEMBL19600977 | 0.79 | MCHR1 (0.38) | DRD2DRD3MCHR1HTR2A | |
| SCHEMBL23132624 | 0.79 | ADRA2A (0.33) | DRD2DRD3HTR2A | |
| SCHEMBL22042262 | 0.75 | DRD2 (0.39) | DRD2DRD4DRD3OPRK1PBRM1 | |
| SCHEMBL6822435 | 0.74 | CYP19A1 (0.47) | DRD2DRD3 | |
| SCHEMBL6080770 | 0.73 | HTR2A (0.53) | DRD2DRD3HTR2A | |
| SCHEMBL31344788 | 0.72 | DRD2 (0.37) | DRD2DRD4DRD3OPRK1PBRM1 | |
| SCHEMBL21556956 | 0.71 | S1PR1 (0.44) | MAOB | |
| SCHEMBL11211277 | 0.70 | PTGS2 (0.45) | PBRM1ESR1ESR2 | |
| SCHEMBL11632910 | 0.69 | DRD4 (0.50) | DRD2DRD4DRD3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170327439-A1 | DIHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327439-A1 | DIHYDRONAPHTHALENE DERIVATIVE | S1PR5, LPAR5, S1PR1 | DRD2 104/4885DRD4 224/4885DRD3 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.