Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LGMN | Q99538 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16744504 | 0.85 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2HPGDALDH1A3ALOX15 | |
| SCHEMBL17871698 | 0.83 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2HPGDALDH1A3MEN1 | |
| SCHEMBL28621356 | 0.81 | HTR1A (0.51) | — | |
| SCHEMBL16577084 | 0.81 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HPGDALDH1A3ALOX15 | |
| SCHEMBL25691836 | 0.79 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2ALDH1A3MEN1TSHR | |
| SCHEMBL20018697 | 0.79 | MAPT (0.49) | ALDH1A1SMN1; SMN2HPGDHSD17B10MEN1 | |
| SCHEMBL17871811 | 0.78 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HSD17B10MEN1TSHR | |
| SCHEMBL25487206 | 0.77 | SMN1; SMN2 (0.49) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL18914793 | 0.77 | LMNA (0.47) | ALDH1A1SMN1; SMN2LGMNALOX15MAPK10 | |
| SCHEMBL29417642 | 0.77 | LMNA (0.47) | ALDH1A1SMN1; SMN2LGMNALOX15MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10030020-B2 | Spirocycle compounds and methods of making and using same | ABIDE THERAPEUTICS, INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-20170327500-A1 | SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327500-A1 | SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ABHD6, ABHD16A, ACSL6 | ALDH1A1 932/4885SMN1; SMN2 1888/4885LGMN 2964/4885 |
| US-10030020-B2 | Spirocycle compounds and methods of making and using same | ABHD6, ABHD16A, ACSL6 | ALDH1A1 932/4885SMN1; SMN2 1888/4885LGMN 2964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.