Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 15/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2894935 | 0.89 | TLR7 (0.49) | TLR7TLR8GAAHTTPDE4A | |
| SCHEMBL4491917 | 0.88 | MAPT (0.44) | TLR7TLR8GAAKDM4ETP53 | |
| SCHEMBL4078508 | 0.88 | LMNA (0.37) | TLR7GAAHTTKDM4ELMNA | |
| SCHEMBL5616965 | 0.87 | TLR7 (0.52) | TLR7TLR8GAAHTTKDM4E | |
| SCHEMBL4165503 | 0.83 | TLR7 (0.49) | TLR7TLR8GAAHTTKDM4E | |
| SCHEMBL1960130 | 0.83 | TLR7 (0.70) | TLR7TLR8 | |
| SCHEMBL5617063 | 0.83 | FAAH (0.48) | TLR7TLR8GAAHTTPDE4A | |
| SCHEMBL3969036 | 0.83 | TLR7 (0.62) | TLR7TLR8PDE4APDE4BPDE4C | |
| SCHEMBL1960054 | 0.82 | TLR7 (0.42) | TLR7TLR8GAAHTTKDM4E | |
| SCHEMBL5617119 | 0.82 | TLR7 (0.45) | TLR7TLR8GAAHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507237-A1 | IMIDAZOQUINOLINES WHICH ACT VIA TOLL - LIKE RECEPTORS (TLR) | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068233-A1 | IMIDAZOQUINOLINES WHICH ACT VIA TOLL - LIKE RECEPTORS (TLR) | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-06-09 | — | — | WO | disclosed |