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SCHEMBL1960680

SCHEMBL1960680

COC(=O)C(CC(=O)O)=C(C)c1ccc(Br)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.41
▸ KMT2A Q03164 4/20 0.41
▸ RAB9A P51151 2/20 0.41
▸ MAPT P10636 2/20 0.41
▸ LMNA P02545 1/20 0.41
▸ MAPK1 P28482 1/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.41
▸ RXFP1 Q9HBX9 1/20 0.41
▸ OGG1 O15527 1/20 0.41
▸ CYP1A2 P05177 2/20 0.40
▸ ATM Q13315 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ POLB P06746 1/20 0.40
▸ CTDSP1 Q9GZU7 1/20 0.40
▸ MAOB P27338 1/20 0.39
▸ CES2 O00748 1/20 0.38
▸ CES1 P23141 1/20 0.38
▸ HAO1 Q9UJM8 1/20 0.38
▸ HPGD P15428 1/20 0.38
▸ GSK3B P49841 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1960678 1.00 MEN1 (0.41) MEN1KMT2ARAB9AMAPTLMNA
SCHEMBL1959256 0.85 HAO1 (0.45) MEN1KMT2ARAB9AMAPTLMNA
SCHEMBL1959255 0.85 HAO1 (0.45) MEN1KMT2ARAB9AMAPTLMNA
SCHEMBL1959253 0.85 HAO1 (0.45) MEN1KMT2ARAB9AMAPTLMNA
SCHEMBL3267872 0.81 NPC1 (0.44) MEN1KMT2ARAB9AMAPTLMNA
SCHEMBL3267871 0.81 NPC1 (0.44) MEN1KMT2ARAB9AMAPTLMNA
SCHEMBL7781993 0.76 KDM4E (0.47) MEN1KMT2ARAB9AMAPTCES2
SCHEMBL4367722 0.76 SMPD1 (0.52) RAB9AMAPTCYP1A2L3MBTL1POLB
SCHEMBL4367720 0.76 SMPD1 (0.52) RAB9AMAPTCYP1A2L3MBTL1POLB
SCHEMBL7789734 0.75 KDM4E (0.56) RAB9AMAPTLMNACYP1A2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10689317-B2 Methods of making fused ring compounds TRANSITIONS OPTICAL, INC. (US) 2020-06-23 — — US disclosed
US-20180148396-A1 Methods of Making Fused Ring Compounds TRANSITIONS OPTICAL, INC. 2018-05-31 — — US disclosed
US-9878971-B2 Methods of making fused ring compounds TRANSITIONS OPTICAL, INC. (US) 2018-01-30 — — US disclosed
EP-2651913-B1 INDENO-FUSED RING COMPOUNDS HAVING PHOTOCHROMIC PROPERTIES TRANSITIONS OPTICAL INC (US) 2017-04-19 — — EP disclosed
US-20170050909-A1 Methods of Making Fused Ring Compounds TRANSITIONS OPTICAL, INC. 2017-02-23 — — US disclosed
US-9487499-B2 Methods of making fused ring compounds TRANSITIONS OPTICAL, INC. (US) 2016-11-08 — — US disclosed
US-9309455-B2 Indeno-fused ring compounds TRANSITIONS OPTICAL, INC. (US) 2016-04-12 — — US disclosed
EP-2652552-B9 PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS TRANSITIONS OPTICAL INC (US) 2016-02-17 — — EP disclosed
US-20150336922-A1 Methods Of Making Fused Ring Compounds TRANSITIONS OPTICAL LIMITED (IE) 2015-11-26 — — US disclosed
US-9139571-B2 Methods of making fused ring compounds TRANSITIONS OPTICAL, INC. (US) 2015-09-22 — — US disclosed
EP-2652552-A1 PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS Transitions Optical, Inc. (US) 2013-10-23 — — EP disclosed
EP-2651913-A1 INDENO- FUSED RING COMPOUNDS HAVING PHOTOCHROMIC PROPERTIES Transitions Optical, Inc. (US) 2013-10-23 — — EP disclosed
US-8545984-B2 Photochromic compounds and compositions TRANSITIONS OPTICAL, INC. (US) 2013-10-01 — — US disclosed
WO-2012082299-A1 PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS TRANSITIONS OPTICAL, INC. (US) 2012-06-21 — — WO disclosed
US-20120157678-A1 METHODS OF MAKING FUSED RING COMPOUNDS TRANSITIONS OPTICAL INC. (US) 2012-06-21 — — US disclosed
WO-2012082381-A1 INDENO- FUSED RING COMPOUNDS HAVING PHOTOCHROMIC PROPERTIES TRANSITIONS OPTICAL, INC. (US) 2012-06-21 — — WO disclosed
WO-2012082560-A1 METHODS OF MAKING FUSED RING COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2012-06-21 — — WO disclosed
US-20120126185-A1 INDENO-FUSED RING COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2012-05-24 — — US disclosed
US-20110140056-A1 Indeno-fused ring compounds TRANSITIONS OPTICAL, INC. (US) 2011-06-16 — — US disclosed
US-20110129678-A1 Photochromic compounds and compositions TRANSITIONS OPTICAL, INC. (US) 2011-06-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10689317-B2 Methods of making fused ring compounds CYP2B6, CYP2A6, INTS6 MEN1 846/4885KMT2A 2818/4885RAB9A 4054/4885
US-20180148396-A1 Methods of Making Fused Ring Compounds CYP2B6, CYP2A6, INTS6 MEN1 846/4885KMT2A 2818/4885RAB9A 4054/4885
US-20170050909-A1 Methods of Making Fused Ring Compounds CYP2B6, CYP2A6, INTS6 MEN1 846/4885KMT2A 2818/4885RAB9A 4054/4885
US-20110140056-A1 Indeno-fused ring compounds CRY2, SQOR, INTS6 MEN1 3740/4885KMT2A 386/4885RAB9A 1640/4885
US-20150336922-A1 Methods Of Making Fused Ring Compounds CYP2B6, CYP2A6, INTS6 MEN1 846/4885KMT2A 2818/4885RAB9A 4054/4885
US-20110129678-A1 Photochromic compounds and compositions CRY2, CRY1, PPOX MEN1 3110/4885KMT2A 1960/4885RAB9A 2888/4885
US-20120126185-A1 INDENO-FUSED RING COMPOUNDS CRY2, SQOR, INTS6 MEN1 3740/4885KMT2A 386/4885RAB9A 1640/4885
US-20120157678-A1 METHODS OF MAKING FUSED RING COMPOUNDS CYP2B6, CYP2A6, INTS6 MEN1 846/4885KMT2A 2818/4885RAB9A 4054/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.