SCHEMBL1961116

SCHEMBL1961116

CSCc1cnc(Cl)c(F)c1

nearest known ligand 0.33

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2746564 0.81 NPSR1 (0.38)
SCHEMBL18929521 0.79 VRK1 (0.33)
SCHEMBL6468592 0.79 TLR7 (0.38) TLR7
SCHEMBL2746687 0.78 CYP11B1 (0.46)
Hydrogen Sulfide SCHEMBL2746723 0.76 CYP11B1 (0.45)
Hydrogen Sulfide SCHEMBL2746720 0.76 CYP11B1 (0.45)
SCHEMBL487436 0.76 TLR7 (0.33) TLR7
SCHEMBL13548295 0.76 RAB9A (0.45) TLR7
SCHEMBL2746674 0.75 MAPT (0.40)
SCHEMBL335231 0.75 RECQL (0.39) TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2338882-B1 2-((6-(Haloalkyl substituted))pyridin-3-yl)-tetrahydro-1H-1(lamba)4-thien-1-ylidenecyanamide derivatives and related compounds as pesticides and insecticides DOW AGROSCIENCES LLC (US) 2017-06-07 EP disclosed
EP-2079697-B1 MULTI-SUBSTITUTED PYRIDYL SULFOXIMINES AND THEIR USE AS INSECTICIDES DOW AGROSCIENCES LLC (US) 2013-06-05 EP disclosed
EP-2079697-B1 MULTI-SUBSTITUTED PYRIDYL SULFOXIMINES AND THEIR USE AS INSECTICIDES DOW AGROSCIENCES LLC (US) 2013-06-05 EP disclosed
US-8188292-B2 Insecticidal N-substituted (heteroaryl)alkyl sulfilimines DOW AGROSCIENCES, LLC (US) 2012-05-29 US disclosed
US-8188292-B2 Insecticidal N-substituted (heteroaryl)alkyl sulfilimines DOW AGROSCIENCES, LLC (US) 2012-05-29 US disclosed
US-8188292-B2 Insecticidal N-substituted (heteroaryl)alkyl sulfilimines DOW AGROSCIENCES, LLC (US) 2012-05-29 US disclosed
US-8178565-B2 Multi-substituted pyridyl sulfoximines and their use as insecticides DOW AGROSCIENCES LLC (US) 2012-05-15 US disclosed
US-8178565-B2 Multi-substituted pyridyl sulfoximines and their use as insecticides DOW AGROSCIENCES LLC (US) 2012-05-15 US disclosed
US-8178565-B2 Multi-substituted pyridyl sulfoximines and their use as insecticides DOW AGROSCIENCES LLC (US) 2012-05-15 US disclosed
EP-2338882-A1 Insecticidal n-substituted (heteroaryl)alkyl sulfilimines Dow AgroSciences LLC (US) 2011-06-29 EP disclosed
US-20080280915-A1 Insecticidal n-substituted (heteroaryl)alkyl sulfilimines CORTEVA AGRISCIENCE LLC 2008-11-13 US disclosed
US-20080280915-A1 Insecticidal n-substituted (heteroaryl)alkyl sulfilimines CORTEVA AGRISCIENCE LLC 2008-11-13 US disclosed
US-20080280915-A1 Insecticidal n-substituted (heteroaryl)alkyl sulfilimines CORTEVA AGRISCIENCE LLC 2008-11-13 US disclosed
WO-2008057129-A1 MULTI-SUBSTITUTED PYRIDYL SULFOXIMINES AND THEIR USE AS INSECTICIDES DOW AGROSCIENCES LLC (US) 2008-05-15 WO disclosed
WO-2008057129-A1 MULTI-SUBSTITUTED PYRIDYL SULFOXIMINES AND THEIR USE AS INSECTICIDES DOW AGROSCIENCES LLC (US) 2008-05-15 WO disclosed
US-20080108667-A1 Multi-substituted pyridyl sulfoximines and their use as insecticides CORTEVA AGRISCIENCE LLC 2008-05-08 US disclosed
US-20080108667-A1 Multi-substituted pyridyl sulfoximines and their use as insecticides CORTEVA AGRISCIENCE LLC 2008-05-08 US disclosed
US-20080108667-A1 Multi-substituted pyridyl sulfoximines and their use as insecticides CORTEVA AGRISCIENCE LLC 2008-05-08 US disclosed
WO-2008030266-A2 INSECTICIDAL N-SUBSTITUTED (HETEROARYL)ALKYL SULFILMINES DOW AGROSCIENCES LLC (US) 2008-03-13 WO disclosed
WO-2008030266-A2 INSECTICIDAL N-SUBSTITUTED (HETEROARYL)ALKYL SULFILMINES DOW AGROSCIENCES LLC (US) 2008-03-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080280915-A1 Insecticidal n-substituted (heteroaryl)alkyl sulfilimines AANAT, GNMT, STS TLR7 2324/4885
US-20080108667-A1 Multi-substituted pyridyl sulfoximines and their use as insecticides PIR, PNPO, PRDX4 TLR7 1142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.