Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 4/20 | 0.53 |
| ▸ | PHF8 | Q9UPP1 | 4/20 | 0.53 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.53 |
| ▸ | KDM4A | O75164 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | NAAA | Q02083 | 2/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9061840 | 1.00 | KDM5A (0.53) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL9089300 | 1.00 | KDM5A (0.53) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL384147 | 0.98 | KDM5A (0.50) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL6521504 | 0.98 | KDM5A (0.51) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL6519311 | 0.98 | KDM5A (0.51) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL1283873 | 0.92 | CYP1A2 (0.46) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL11855794 | 0.90 | KDM5A (0.49) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL11847166 | 0.90 | KDM5A (0.49) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL11856253 | 0.90 | KDM5A (0.49) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL11851812 | 0.90 | KDM5A (0.49) | KDM5APHF8KDM2AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074788-B | Substituted heterocyclic derivatives, preparation method and application thereof | 厦门大学 | 2019-09-20 | — | — | CN | disclosed |
| US-10174015-B2 | Substituted heterocyclic derivative, preparation method and use thereof | XIAMEN UNIVERSITY (CN) | 2019-01-08 | — | — | US | disclosed |
| US-20170334896-A1 | Substituted Heterocyclic Derivative, Preparation Method And Use Thereof | XIAMEN UNIVERSITY (CN) | 2017-11-23 | — | — | US | disclosed |
| CN-107074788-A | Substituted heterocyclic derivatives, preparation method and application thereof | 厦门大学 | 2017-08-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334896-A1 | Substituted Heterocyclic Derivative, Preparation Method And Use Thereof | FAAH, NAAA, FAAH2 | KDM5A 1211/4885PHF8 856/4885KDM2A 1729/4885 |
| US-10174015-B2 | Substituted heterocyclic derivative, preparation method and use thereof | DHPS, CYP3A5, CYP3A4 | KDM5A 399/4885PHF8 1174/4885KDM2A 1418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.