Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL195906 | 0.83 | GABRA5 (0.61) | ALDH1A1POLBGABRA5PTGS1CASP6 | |
| SCHEMBL195905 | 0.83 | GABRA5 (0.61) | ALDH1A1POLBGABRA5PTGS1CASP6 | |
| SCHEMBL196378 | 0.80 | ALDH1A1 (0.46) | KMT2AALDH1A1GAAPOLBKDM4E | |
| SCHEMBL196222 | 0.76 | PRKCE (0.34) | ALDH1A1GAAPOLBKDM4ESMN1; SMN2 | |
| SCHEMBL195999 | 0.75 | POLB (0.49) | KMT2AGAAPOLBGABRA5MEN1 | |
| SCHEMBL196000 | 0.75 | POLB (0.49) | KMT2AGAAPOLBGABRA5MEN1 | |
| SCHEMBL195442 | 0.74 | GABRA5 (0.63) | GABRA5 | |
| SCHEMBL195443 | 0.74 | GABRA5 (0.63) | GABRA5 | |
| SCHEMBL14796906 | 0.71 | GABRA5 (0.54) | GABRA5 | |
| SCHEMBL285938 | 0.70 | ALDH1A1 (0.48) | ALDH1A1POLBKDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389550-B2 | Isoxazoles / O-pyridines with ethyl and ethenyl linker | HOFFMANN-LA ROCHE INC. (US) | 2013-03-05 | — | — | US | disclosed |
| EP-2401271-A1 | ISOXAZOLE / O-PYRIDINE DERIVATIVES WITH ETHYL AND ETHENYL LINKER AS GABA A ALPHA5 RECEPTOR INVERSE AGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097368-A1 | ISOXAZOLE / O-PYRIDINE DERIVATIVES WITH ETHYL AND ETHENYL LINKER | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-02 | — | — | WO | disclosed |
| US-20100216845-A1 | ISOXAZOLES / O-PYRIDINES WITH ETHYL AND ETHENYL LINKER | ROCHE PALO ALTO LLC | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216845-A1 | ISOXAZOLES / O-PYRIDINES WITH ETHYL AND ETHENYL LINKER | GABRA5, GABRA1, GABRA4 | KMT2A 3435/4885ALDH1A1 307/4885GAA 2853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.