Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL195458 | 0.82 | GABRA5 (0.41) | KDM4EMAPTMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL195457 | 0.82 | GABRA5 (0.41) | KDM4EMAPTMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL196160 | 0.79 | ALDH1A1 (0.35) | PRKCEPRKCQPRKCDKDM4EMAPT | |
| SCHEMBL196201 | 0.76 | KMT2A (0.46) | KDM4EHSD17B10SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL2672813 | 0.74 | ALDH1A1 (0.35) | MAPTSMN1; SMN2ALDH1A1L3MBTL1LMNA | |
| SCHEMBL14797029 | 0.74 | HCAR3 (0.41) | KDM4EMAPTSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL2672809 | 0.74 | ALDH1A1 (0.35) | MAPTSMN1; SMN2ALDH1A1L3MBTL1LMNA | |
| SCHEMBL14797027 | 0.74 | HCAR3 (0.41) | KDM4EMAPTSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL196305 | 0.73 | GABRA5 (0.46) | GABRA1GABRA5 | |
| SCHEMBL196306 | 0.73 | GABRA5 (0.46) | GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401271-B1 | ISOXAZOLE / O-PYRIDINE DERIVATIVES WITH ETHYL AND ETHENYL LINKER AS GABA A ALPHA5 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2013-03-27 | — | — | EP | disclosed |
| US-8389550-B2 | Isoxazoles / O-pyridines with ethyl and ethenyl linker | HOFFMANN-LA ROCHE INC. (US) | 2013-03-05 | — | — | US | disclosed |
| EP-2401271-A1 | ISOXAZOLE / O-PYRIDINE DERIVATIVES WITH ETHYL AND ETHENYL LINKER AS GABA A ALPHA5 RECEPTOR INVERSE AGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097368-A1 | ISOXAZOLE / O-PYRIDINE DERIVATIVES WITH ETHYL AND ETHENYL LINKER | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-02 | — | — | WO | disclosed |
| US-20100216845-A1 | ISOXAZOLES / O-PYRIDINES WITH ETHYL AND ETHENYL LINKER | ROCHE PALO ALTO LLC | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216845-A1 | ISOXAZOLES / O-PYRIDINES WITH ETHYL AND ETHENYL LINKER | GABRA5, GABRA1, GABRA4 | PRKCE 1823/4885PRKCQ 2153/4885PRKCD 1499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.