Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.31 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | CCR6 | P51684 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15617163 | 0.94 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2POLBLMNAMAPT | |
| SCHEMBL18106220 | 0.94 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2POLBLMNAMAPT | |
| SCHEMBL49389 | 0.87 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2POLBLMNAMAPT | |
| SCHEMBL20274381 | 0.86 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2ZDHHC20ZDHHC2 | |
| SCHEMBL18458050 | 0.84 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2LMNAMAPTZDHHC20 | |
| SCHEMBL19493415 | 0.84 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2ZDHHC20ZDHHC2 | |
| SCHEMBL20274451 | 0.82 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL9861082 | 0.82 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2ZDHHC20ZDHHC2 | |
| SCHEMBL21652434 | 0.81 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2POLBKDM4EMAPT | |
| SCHEMBL18435904 | 0.81 | ALDH1A1 (0.37) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3359119-B1 | DENTAL COMPOSITION | DENTSPLY DETREY GMBH (DE) | 2021-12-29 | — | — | EP | disclosed |
| US-11000454-B2 | Dental composition | DENTSPLY SIRONA INC. (US) | 2021-05-11 | — | — | US | disclosed |
| US-20190117523-A1 | DENTAL COMPOSITION | DENTSPLY SIRONA INC. (US) | 2019-04-25 | — | — | US | disclosed |
| WO-2017198840-A1 | DENTAL COMPOSITION | DENTSPLY DETREY GMBH (DE) | 2017-11-23 | — | — | WO | disclosed |
| EP-3246001-A1 | DENTAL COMPOSITION | DENTSPLY DETREY GmbH (DE) | 2017-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11000454-B2 | Dental composition | PPIP5K2, INPP5D, DCPS | ALDH1A1 1990/4885SMN1; SMN2 4499/4885POLB 583/4885 |
| US-20190117523-A1 | DENTAL COMPOSITION | PPIP5K2, INPP5D, DCPS | ALDH1A1 1990/4885SMN1; SMN2 4499/4885POLB 583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.