Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1962703 | 0.76 | FAAH (0.68) | CYP11B2CHRNB2CHRNA5CHRNA4TSHR | |
| SCHEMBL1959447 | 0.75 | CYP11B2 (0.53) | CYP11B2CHRNB2CHRNA5CHRNA4CYP11B1 | |
| SCHEMBL1959026 | 0.74 | FAAH (0.52) | CYP11B2CHRNB2CHRNA5CHRNA4CYP19A1 | |
| SCHEMBL1680266 | 0.70 | CYP2A6 (0.49) | CYP11B2CHRNB2CHRNA5CHRNA4CYP11B1 | |
| SCHEMBL20356849 | 0.70 | CYP2A6 (0.45) | CHRNB2CHRNA5CHRNA4GSK3AGSK3B | |
| SCHEMBL2689301 | 0.70 | CYP2A6 (0.45) | CHRNB2CHRNA5CHRNA4GAANPC1 | |
| SCHEMBL22795878 | 0.69 | PTGS2 (0.57) | TSHRGAANPC1RAB9A | |
| SCHEMBL27812580 | 0.68 | CYP2A6 (0.51) | CYP11B2CHRNB2CHRNA5CHRNA4CYP11B1 | |
| SCHEMBL6886740 | 0.68 | AR (0.52) | CYP11B2CHRNB2CHRNA5CHRNA4CYP11B1 | |
| SCHEMBL30712752 | 0.67 | CYP11B2 (1.00) | CYP11B2CHRNB2CHRNA5CHRNA4CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2299824-B1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK SHARP & DOHME (US) | 2013-06-19 | — | — | EP | disclosed |
| US-20110144056-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK SHARP & DOHME CORP. | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144056-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | FAAH, FAAH2, HRH2 | CYP11B2 528/4885CHRNB2 2405/4885CHRNA5 504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.