Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | DDO | Q99489 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19625002 | 0.82 | MCL1 (0.35) | MCL1 | |
| SCHEMBL19624951 | 0.74 | TBXAS1 (0.36) | DAOIDO1KDM4EALDH1A1GAA | |
| SCHEMBL19625090 | 0.74 | FLT3 (0.53) | SRD5A2GRIN2DGRIN1GRIN2AGRIN2B | |
| SCHEMBL19625006 | 0.70 | SLC9A1 (0.39) | SRD5A2GRIN2DGRIN1GRIN2AGRIN2B | |
| SCHEMBL19625088 | 0.69 | MCL1 (0.33) | MCL1 | |
| SCHEMBL19625091 | 0.68 | MCL1 (0.33) | MCL1 | |
| SCHEMBL13656742 | 0.68 | KAT2B (0.40) | MCL1KDM4EALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL27511754 | 0.67 | AHR (0.42) | HTR6DAOMCL1MEN1GAA | |
| SCHEMBL24112993 | 0.64 | DAO (0.58) | HTR6DAODDOSRD5A2GRIN2D | |
| SCHEMBL22395238 | 0.64 | KDM4E (0.58) | HTR6DAODDOSRD5A2GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892880-B1 | INDOLE CARBOXAMIDE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2017-11-22 | — | — | EP | disclosed |