Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 2/20 | 0.52 |
| ▸ | ATP4B | P51164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19625329 | 0.83 | NPC1 (0.43) | ATP4AATP4BMAPTSMN1; SMN2RAB9A | |
| SCHEMBL12282550 | 0.82 | RAB9A (0.54) | MAPTSMN1; SMN2PTGS2RAB9ANPC1 | |
| SCHEMBL19625383 | 0.81 | SMN1; SMN2 (0.46) | ATP4AATP4BMAPTSMN1; SMN2RAB9A | |
| SCHEMBL19626485 | 0.81 | GAA (0.57) | ATP4AATP4BMAPTSMN1; SMN2RAB9A | |
| SCHEMBL12282347 | 0.79 | LTA4H (0.58) | ATP4AATP4BMAPTSMN1; SMN2PTGS2 | |
| SCHEMBL19625332 | 0.79 | RAB9A (0.58) | MAPTSMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL19625300 | 0.79 | RAB9A (0.56) | MAPTSMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL799889 | 0.79 | RAB9A (0.56) | MAPTSMN1; SMN2PTGS2RAB9ANPC1 | |
| SCHEMBL19625353 | 0.79 | ATP4A (0.49) | ATP4AATP4BMAPTSMN1; SMN2RAB9A | |
| SCHEMBL26014382 | 0.79 | RAB9A (0.58) | ATP4AATP4BMAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | ATP4A 1734/4885ATP4B 1169/4885MAPT 4783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.