Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.64 |
| ▸ | RAB9A | P51151 | 10/20 | 0.64 |
| ▸ | NPC1 | O15118 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | STAT1 | P42224 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496545 | 0.87 | PTGS1 (0.65) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL23402744 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL6451935 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL1143708 | 0.78 | RAB9A (1.00) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL13869061 | 0.77 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2608434 | 0.77 | ALDH1A1 (0.61) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL19626646 | 0.76 | SMN1; SMN2 (0.64) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL12859412 | 0.76 | MAPT (0.44) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL28616976 | 0.75 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL12298702 | 0.74 | CDK8 (0.54) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472360-B2 | Purine diones as Wnt pathway modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-11-12 | — | — | US | disclosed |
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | SMN1; SMN2 4828/4885RAB9A 3162/4885NPC1 2489/4885 |
| US-10472360-B2 | Purine diones as Wnt pathway modulators | WNT1, WNT3A, CTNNB1 | SMN1; SMN2 4828/4885RAB9A 3162/4885NPC1 2489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.