Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 13/20 | 0.51 |
| ▸ | NPC1 | O15118 | 11/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19625304 | 0.87 | KMT2A (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL19625312 | 0.86 | RAB9A (0.59) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL19627035 | 0.84 | RAB9A (0.70) | KIF11RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1692265 | 0.81 | PIM1 (0.52) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL19625477 | 0.77 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL19625453 | 0.76 | MEN1 (0.53) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL12282347 | 0.76 | LTA4H (0.58) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL19625353 | 0.76 | ATP4A (0.49) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL12282550 | 0.75 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL126387 | 0.74 | KMT2A (0.66) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472360-B2 | Purine diones as Wnt pathway modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-11-12 | — | — | US | disclosed |
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | KIF11 4813/4885RAB9A 3162/4885NPC1 2489/4885 |
| US-10472360-B2 | Purine diones as Wnt pathway modulators | WNT1, WNT3A, CTNNB1 | KIF11 4813/4885RAB9A 3162/4885NPC1 2489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.