Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | KCNA2 | P16389 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL79942 | 0.86 | HPGD (0.56) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL19625791 | 0.84 | PTPN1 (0.52) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL10247058 | 0.81 | PTPN1 (0.47) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL27389748 | 0.80 | L3MBTL1 (0.66) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL82592 | 0.78 | THRB (0.43) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL16441037 | 0.78 | KCNA2 (0.49) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL21668583 | 0.77 | MAPT (0.74) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL19755568 | 0.77 | LMNA (0.53) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL81427 | 0.76 | HPGD (0.49) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL24162183 | 0.75 | MAPT (0.67) | MAPTCYP2C9CYP2C19SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148412-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATE OF DOLUTEGRAVIR | HETERO RESEARCH FOUNDATION (IN) | 2018-05-31 | — | — | US | disclosed |
| US-9963430-B2 | Process for the preparation of intermediate of dolutegravir | HETERO RESEARCH FOUNDATION (IN) | 2018-05-08 | — | — | US | disclosed |
| US-20170334858-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATE OF DOLUTEGRAVIR | HETERO RESEARCH FOUNDATION (IN) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334858-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATE OF DOLUTEGRAVIR | CYP3A4, DHPS, MVD | MAPT 3690/4885CYP2C9 7/4885CYP2C19 4/4885 |
| US-20180148412-A1 | PROCESS FOR THE PREPARATION OF INTERMEDIATE OF DOLUTEGRAVIR | CYP3A4, DHPS, MVD | MAPT 3690/4885CYP2C9 7/4885CYP2C19 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.