Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12490666 | 0.91 | MAPK13 (0.53) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL31194856 | 0.84 | PTGS2 (0.74) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL31194859 | 0.84 | MAPK13 (0.57) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL14664024 | 0.84 | MAPK13 (0.57) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL31194860 | 0.84 | MAPK13 (0.57) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL2091239 | 0.83 | MAPK13 (0.83) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL14195802 | 0.82 | NPC1 (0.56) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL31194858 | 0.81 | MAPK13 (0.54) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL8192267 | 0.81 | ENPP3 (0.42) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL25351821 | 0.80 | NR4A2 (0.67) | MAPK13MAPK12MAPK11MAPK14PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | MAPK13 1744/4885MAPK12 1157/4885MAPK11 1891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.