Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19626665 | 0.81 | GAA (0.44) | TERTALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL19625452 | 0.81 | PTGS2 (0.40) | TERTGRIA2GRIN1GRIN2AALDH1A1 | |
| SCHEMBL19626771 | 0.81 | DHFR (0.38) | TERTALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL19626781 | 0.80 | CYP3A4 (0.40) | TERTGRIA2GRIN1GRIN2AALDH1A1 | |
| SCHEMBL19626651 | 0.78 | PTGS2 (0.56) | ALDH1A1MAPTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL19626765 | 0.77 | GRIA2 (0.32) | TERTGRIA2GRIN1GRIN2AALDH1A1 | |
| SCHEMBL19626656 | 0.76 | PPARD (0.41) | TERTGRIA2GRIN1GRIN2AALDH1A1 | |
| SCHEMBL19626744 | 0.75 | PTGDR2 (0.53) | ALDH1A1MAPTHPGDKDM4ESMN1; SMN2 | |
| SCHEMBL17625955 | 0.72 | ALDH1A1 (0.40) | TERTALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL19626588 | 0.70 | ALDH1A1 (0.42) | TERTGRIA2GRIN1GRIN2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | TERT 2609/4885GRIA2 3043/4885GRIN1 3322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.