Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19626643 | 0.89 | PTGS2 (0.55) | KDM4EALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL19625350 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL19626571 | 0.80 | ALDH1A1 (0.51) | KDM4EALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL10120489 | 0.79 | KDM4E (0.71) | KDM4EALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL19626668 | 0.78 | KDM4E (0.48) | KDM4EALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL8077905 | 0.77 | JAK2 (0.51) | KDM4EALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL20716114 | 0.76 | PTGS2 (0.67) | KDM4EALDH1A1HPGDLMNAMAPT | |
| SCHEMBL19626496 | 0.75 | ALDH1A1 (0.40) | KDM4EALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL14754361 | 0.75 | KMO (0.40) | KDM4EALDH1A1CYP3A4HPGDALOX15 | |
| SCHEMBL17626002 | 0.74 | KMO (0.40) | KDM4EALDH1A1CYP3A4HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | KDM4E 3779/4885ALDH1A1 1166/4885CYP3A4 419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.