Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17830453 | 0.79 | TAAR1 (0.54) | KCNN4ALDH1A1KDM4ETDP1HRH1 | |
| SCHEMBL12000666 | 0.79 | TDP1 (0.43) | KCNN4ALDH1A1KDM4ETDP1CYP2D6 | |
| SCHEMBL19629886 | 0.79 | KCNN4 (0.46) | KCNN4ALDH1A1KDM4ECYP2D6CYP2C19 | |
| SCHEMBL2898487 | 0.75 | CYP2D6 (0.41) | KCNN4ALDH1A1KDM4ETDP1CYP2D6 | |
| SCHEMBL22458610 | 0.73 | SIGMAR1 (0.40) | KCNN4ALDH1A1KDM4ETDP1CYP2D6 | |
| SCHEMBL31479981 | 0.73 | MEN1 (0.51) | KCNN4ALDH1A1KDM4ETDP1CYP3A4 | |
| SCHEMBL3755365 | 0.71 | HDAC3 (0.41) | KCNN4CYP2C19KMT2AOPRM1DRD3 | |
| SCHEMBL11668769 | 0.71 | KCNN4 (0.52) | KCNN4ALDH1A1KDM4ECYP2D6CYP2C19 | |
| SCHEMBL28111885 | 0.70 | ALDH1A1 (0.40) | ALDH1A1KDM4ETDP1CYP2D6CYP2C19 | |
| SCHEMBL31646704 | 0.70 | TAAR1 (0.58) | KCNN4CYP2D6CYP2C19CYP3A4TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10358437-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-07-23 | — | — | US | disclosed |
| US-10316023-B2 | — | — | 2019-06-11 | — | — | US | disclosed |
| US-20170334883-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170334883-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10316023-B2 | — | PKD1, NHERF1, PCSK6 | KCNN4 1385/4885ALDH1A1 1008/4885KDM4E 1884/4885 |
| US-20170334883-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | PKD1, NHERF1, HDAC10 | KCNN4 1907/4885ALDH1A1 782/4885KDM4E 1688/4885 |
| US-10358437-B2 | Therapeutic compounds and uses thereof | PKD1, NHERF1, HDAC10 | KCNN4 1907/4885ALDH1A1 782/4885KDM4E 1688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.