Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.72 |
| ▸ | NPC1 | O15118 | 7/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | RECQL | P46063 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19625376 | 0.85 | RAB9A (0.53) | RAB9ASMN1; SMN2NPC1ALDH1A1HSD17B10 | |
| SCHEMBL16601588 | 0.84 | RAB9A (1.00) | RAB9ASMN1; SMN2NPC1ALDH1A1HSD17B10 | |
| SCHEMBL12987199 | 0.81 | RAB9A (0.73) | RAB9ASMN1; SMN2NPC1ALDH1A1HSD17B10 | |
| SCHEMBL13238168 | 0.78 | SMN1; SMN2 (1.00) | RAB9ASMN1; SMN2NPC1ALDH1A1HSD17B10 | |
| SCHEMBL13850927 | 0.77 | PLA2G10 (0.51) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL2554242 | 0.77 | RAB9A (0.55) | RAB9ASMN1; SMN2NPC1ALDH1A1HSD17B10 | |
| SCHEMBL22334909 | 0.76 | ALDH1A1 (0.65) | RAB9ASMN1; SMN2NPC1ALDH1A1HSD17B10 | |
| SCHEMBL18611250 | 0.76 | ALDH1A1 (0.69) | RAB9ASMN1; SMN2NPC1ALDH1A1HSD17B10 | |
| SCHEMBL586497 | 0.73 | ALDH1A1 (0.55) | RAB9ASMN1; SMN2NPC1ALDH1A1HSD17B10 | |
| SCHEMBL7368730 | 0.72 | RAB9A (1.00) | RAB9ASMN1; SMN2NPC1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | RAB9A 3162/4885SMN1; SMN2 4828/4885NPC1 2489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.