Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19625403 | 0.80 | PTGDR2 (0.38) | ALDH1A1PTGDR2PTGS2MEN1KMT2A | |
| SCHEMBL19627032 | 0.80 | CYP1A2 (0.40) | PTGDR2MEN1KMT2AALOX5F2RL3 | |
| SCHEMBL2090659 | 0.79 | ALDH1A1 (0.61) | ALDH1A1HPGDPTGDR2PTGS1PTGS2 | |
| SCHEMBL791528 | 0.77 | PTGDR2 (0.61) | ALDH1A1HPGDPTGDR2PTGS1PTGS2 | |
| SCHEMBL19626744 | 0.76 | PTGDR2 (0.53) | ALDH1A1HPGDPTGDR2PTGS1PTGS2 | |
| SCHEMBL2090657 | 0.76 | PTGDR2 (0.53) | ALDH1A1HPGDPTGDR2PTGS1PTGS2 | |
| SCHEMBL6631658 | 0.75 | PTGDR2 (0.51) | ALDH1A1HPGDPTGDR2PTGS1PTGS2 | |
| SCHEMBL6492363 | 0.74 | PTGDR2 (0.55) | ALDH1A1HPGDPTGDR2PTGS1PTGS2 | |
| SCHEMBL19626751 | 0.74 | PTGDR2 (0.66) | ALDH1A1HPGDPTGDR2PTGS1PTGS2 | |
| SCHEMBL7841482 | 0.72 | PTGS2 (0.65) | ALDH1A1PTGDR2PTGS1PTGS2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | ALDH1A1 1166/4885HPGD 1547/4885PTGDR2 443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.