Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.36 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19929298 | 0.86 | GAA (0.41) | PRKCZMAPTGAALMNAKDM4E | |
| SCHEMBL19628290 | 0.73 | PRKCZ (0.36) | PRKCZ | |
| SCHEMBL10173672 | 0.71 | MAPT (0.36) | MAPTLMNAALDH1A1KMT2A | |
| SCHEMBL19628291 | 0.68 | MAPT (0.50) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL16920140 | 0.66 | NPC1 (0.43) | MAPTGAALMNAKDM4EPKM | |
| SCHEMBL21519749 | 0.65 | TDP1 (0.53) | TSHRMAPTLMNATP53ALDH1A1 | |
| SCHEMBL14469746 | 0.64 | TSHR (0.40) | PRKCZTSHRMAPTLMNATP53 | |
| SCHEMBL7658905 | 0.63 | ALDH1A1 (0.61) | TSHRMAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL29020301 | 0.63 | SRD5A2 (0.47) | TSHRALDH1A1SLC6A2SLC6A3KMT2A | |
| SCHEMBL23439854 | 0.63 | ALDH1A1 (0.47) | TSHRMAPTLMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | MERCK SHARPE & DOHME CORP. (US) | 2018-03-08 | — | — | US | disclosed |
| US-20170334926-A1 | PROCESS FOR PREPARING SUBSTITUTED INDOLE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334926-A1 | PROCESS FOR PREPARING SUBSTITUTED INDOLE COMPOUNDS | IDO1, IDO2, TPH1 | PRKCZ 4391/4885TSHR 1228/4885MAPT 2778/4885 |
| US-20180065985-A1 | PROCESS FOR MAKING TETRACYCLIC HETEROCYCLE COMPOUNDS | CYP1B1, CYP1A2, CYP2F1 | PRKCZ 4187/4885TSHR 541/4885MAPT 4031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.