Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19628374 | 0.83 | TRPA1 (0.47) | TRPA1MAOATAAR1SLC6A2HPGD | |
| SCHEMBL17905083 | 0.78 | TRPA1 (0.36) | TRPA1MAOAMAOBHPGD | |
| SCHEMBL17760943 | 0.78 | RCE1 (0.41) | TRPA1HTT | |
| SCHEMBL28605534 | 0.77 | TRPA1 (0.41) | TRPA1MAPK1 | |
| SCHEMBL17894775 | 0.77 | TRPA1 (0.41) | TRPA1MAPK1 | |
| SCHEMBL19628385 | 0.77 | TRPA1 (0.58) | TRPA1AOC3MAOAMAOBLOXL2 | |
| SCHEMBL19628382 | 0.77 | TRPA1 (0.69) | TRPA1AOC3MAOAMAOBLOXL2 | |
| SCHEMBL17429780 | 0.77 | TRPA1 (0.50) | TRPA1AOC3MAOAMAOBSMN1; SMN2 | |
| SCHEMBL19754017 | 0.77 | TRPA1 (0.50) | TRPA1AOC3MAOAMAOBSMN1; SMN2 | |
| SCHEMBL16280734 | 0.74 | TRPA1 (0.46) | TRPA1AOC3MAOAMAOBLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180000075-A1 | PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | CORTEVA AGRISCIENCE LLC | 2018-01-04 | — | — | US | disclosed |
| US-20180000085-A1 | USE OF PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | CORTEVA AGRISCIENCE LLC | 2018-01-04 | — | — | US | disclosed |
| US-20170334934-A1 | Macrocyclic picolinamides as fungicides | DOW AGROSCIENCES LLC (US) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334934-A1 | Macrocyclic picolinamides as fungicides | CYP4F12, CYP1A2, FKBP2 | TRPA1 676/4885AOC3 1184/4885MAOA 1834/4885 |
| US-20180000075-A1 | PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | PFAS, CASP2, CYP1A2 | TRPA1 185/4885AOC3 1594/4885MAOA 797/4885 |
| US-20180000085-A1 | USE OF PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | PFAS, CYP1A2, CYP51A1 | TRPA1 246/4885AOC3 1324/4885MAOA 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.