Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | CACNB4 | O00305 | 3/20 | 0.41 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.41 |
| ▸ | CACNG3 | O60359 | 3/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.41 |
| ▸ | CACNB3 | P54284 | 3/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.41 |
| ▸ | CACNG7 | P62955 | 3/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.41 |
| ▸ | CACNG1 | Q06432 | 3/20 | 0.41 |
| ▸ | CACNB2 | Q08289 | 3/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21064126 | 0.90 | GPR119 (0.48) | GPR119TDO2RORCNAAACACNB4 | |
| SCHEMBL15830317 | 0.83 | GPR119 (0.49) | GPR119TDO2NAAACACNB4CACNA1A | |
| SCHEMBL17303522 | 0.82 | GPR119 (0.47) | GPR119TDO2NAAACACNB4CACNA1A | |
| SCHEMBL16217421 | 0.80 | GPR119 (0.52) | GPR119TDO2RORCNAAACACNB4 | |
| SCHEMBL19633442 | 0.79 | NAAA (0.45) | GPR119TDO2RORCNAAACACNB4 | |
| SCHEMBL17072682 | 0.75 | GPR119 (0.43) | GPR119TDO2RORCNAAACACNB4 | |
| SCHEMBL20252452 | 0.75 | HDAC6 (0.38) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL19633720 | 0.74 | GPR119 (0.46) | GPR119TDO2RORC | |
| SCHEMBL20252778 | 0.74 | CACNB4 (0.43) | GPR119TDO2RORCNAAACACNB4 | |
| SCHEMBL15830030 | 0.74 | NAAA (0.48) | GPR119TDO2RORCNAAACACNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10391089-B2 | PRMT5 inhibitors and uses therof | Epizyme, Inc. (US) | 2019-08-27 | — | — | US | disclosed |
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2019-06-04 | — | — | US | disclosed |
| US-20180162847-A1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | Epizyme, Inc. (US) | 2018-06-14 | — | — | US | disclosed |
| US-20170334861-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10391089-B2 | PRMT5 inhibitors and uses therof | PRMT5, PRMT1, PRMT6 | GPR119 1373/4885TDO2 1585/4885RORC 2366/4885 |
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | PRMT5, PRMT1, PRMT3 | GPR119 843/4885TDO2 2634/4885RORC 971/4885 |
| US-20170334861-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT3 | GPR119 843/4885TDO2 2634/4885RORC 971/4885 |
| US-20180162847-A1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | PRMT5, PRMT1, PRMT3 | GPR119 1132/4885TDO2 3069/4885RORC 1267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.